LncRNA H19 is involved in myocardial ischemic preconditioning via increasing the stability of nucleolin protein.
Animals
Apoptosis
/ genetics
Cell Survival
/ genetics
Disease Models, Animal
Humans
Ischemic Preconditioning, Myocardial
Mice
Myocardial Ischemia
/ genetics
Myocardial Reperfusion Injury
/ genetics
Myocytes, Cardiac
/ metabolism
Phosphoproteins
/ genetics
Protein Stability
RNA, Long Noncoding
/ genetics
RNA-Binding Proteins
/ genetics
Rats
Nucleolin
lncRNA H19
myocardial ischemic preconditioning
nucleolin
stability of protein
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
03
07
2019
accepted:
09
01
2020
pubmed:
25
1
2020
medline:
12
3
2021
entrez:
25
1
2020
Statut:
ppublish
Résumé
Myocardial ischemic preconditioning (IP) is defined as a brief period of myocardial ischemia/reperfusion (I/R) that significantly reduces injury during the subsequent exposure to long-term I/R. However, the underlying mechanisms of myocardial IP are yet to be elucidated. This study investigated the expression and roles of long noncoding RNA (lncRNA) H19 in myocardial IP in vitro and in vivo. LncRNA H19 expression levels were analyzed by quantitative reverse-transcription polymerase chain reaction, cell viability was determined by the Cell Counting Kit-8 assay, apoptosis was evaluated based on the caspase 3 activity, and RNA immunoprecipitation was performed to examine the interaction between lncRNA H19 and nucleolin. The results of this study showed that lncRNA H19 expression was significantly upregulated in mouse hearts subjected to myocardial IP, in rat H9C2 cells exposed to H
Substances chimiques
H19 long non-coding RNA
0
Phosphoproteins
0
RNA, Long Noncoding
0
RNA-Binding Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5985-5994Informations de copyright
© 2020 Wiley Periodicals, Inc.
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