Morphological features and pathogenicity of mutated canine influenza viruses from China and South Korea.
Animals
Antibodies, Viral
/ blood
Antigens, Viral
/ immunology
China
Dog Diseases
/ pathology
Dogs
Flow Cytometry
/ veterinary
Influenza A Virus, H1N1 Subtype
/ genetics
Influenza A Virus, H3N2 Subtype
/ genetics
Madin Darby Canine Kidney Cells
Microscopy, Confocal
/ veterinary
Orthomyxoviridae Infections
/ pathology
Phylogeny
Republic of Korea
United States
Virulence
/ physiology
Virus Replication
/ physiology
canine influenza virus
cellular uptake
morphology
pathogenicity
Journal
Transboundary and emerging diseases
ISSN: 1865-1682
Titre abrégé: Transbound Emerg Dis
Pays: Germany
ID NLM: 101319538
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
07
10
2019
revised:
18
01
2020
accepted:
20
01
2020
pubmed:
25
1
2020
medline:
18
7
2020
entrez:
25
1
2020
Statut:
ppublish
Résumé
The canine influenza virus (CIV) has spread globally from East Asia to the United States and mutated and evolved to generate various CIVs. Since 2010, the mutant CIVs found in China and Korea have presented increased virulence in mice, guinea pigs and ferrets, which has raised concerns about public health and outbreak of a severe canine flu. We analysed and compared the morphology, cellular uptake and pathogenicity of CIV variants in host animals, to determine their characteristics. The Chinese mutant, A/canine/Jiangsu/06/2010[H3N2](JS10), has two amino acid insertions at the distal end of the NA stalk, and A/canine/Korea/01/2007[H3N2](KR07) presented comparable efficiency of cell uptake and a similar morphology to spherical or small ovoid particles. However, KR07M generated from swapping of M segment of the pandemic isolate, A/California/04/2009 [H1N1] (CA04) into KR07 alone accounted for morphologic change and higher efficiency of cell uptake to the wild-type CIV. This study will provide an insight into the pathogenesis, transmission and evolution of CIVs and help determine future countermeasures.
Substances chimiques
Antibodies, Viral
0
Antigens, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1607-1613Subventions
Organisme : Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries
ID : 319076-2
Organisme : Bio & Medical Technology Development Program of the National Research Foundation
ID : NRF-2018M3A9H4056339
Organisme : National Natural and Science Foundation of China
ID : 31800161
Organisme : Natural Sciences Foundation of Jiangsu Province
ID : BK20180297
Informations de copyright
© 2020 Blackwell Verlag GmbH.
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