Immunotherapy for Parkinson's disease.
Alzheimer’s disease
Effector T cells
Granulocyte-macrophage colony stimulating factor
Immune homeostasis
Immune transformation
Ischemic stroke
Neurodegeneration
Neurodegenerative disorders
Neuroinflammation
Neuroprotection
Nigrostriatal degeneration
Parkinson’s disease
Regulatory T cells
Teffs
Traumatic brain injury
Tregs
Journal
Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
21
10
2019
revised:
23
12
2019
accepted:
20
01
2020
pubmed:
25
1
2020
medline:
16
1
2021
entrez:
25
1
2020
Statut:
ppublish
Résumé
With the increasing prevalence of Parkinson's disease (PD), there is an immediate need to interdict disease signs and symptoms. In recent years this need was met through therapeutic approaches focused on regenerative stem cell replacement and alpha-synuclein clearance. However, neither have shown long-term clinical benefit. A novel therapeutic approach designed to affect disease is focused on transforming the brain's immune microenvironment. As disordered innate and adaptive immune functions are primary components of neurodegenerative disease pathogenesis, this has emerged as a clear opportunity for therapeutic development. Interventions that immunologically restore the brain's homeostatic environment can lead to neuroprotective outcomes. These have recently been demonstrated in both laboratory and early clinical investigations. To these ends, efforts to increase the numbers and function of regulatory T cells over dominant effector cells that exacerbate systemic inflammation and neurodegeneration have emerged as a primary research focus. These therapeutics show broad promise in affecting disease outcomes beyond PD, such as for Alzheimer's disease, stroke and traumatic brain injuries, which share common neurodegenerative disease processes.
Identifiants
pubmed: 31978602
pii: S0969-9961(20)30035-8
doi: 10.1016/j.nbd.2020.104760
pmc: PMC7933730
mid: NIHMS1675081
pii:
doi:
Substances chimiques
Immunologic Factors
0
alpha-Synuclein
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104760Subventions
Organisme : NINDS NIH HHS
ID : R01 NS036126
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS097195
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145542
Pays : United States
Organisme : NIDA NIH HHS
ID : P01 DA028555
Pays : United States
Organisme : NIMH NIH HHS
ID : P30 MH062261
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS031492
Pays : United States
Organisme : NIDA NIH HHS
ID : P01 DA026146
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI138613
Pays : United States
Organisme : NIMH NIH HHS
ID : P01 MH064570
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG043540
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS070190
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS034239
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH115860
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS043985
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS049264
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH121402
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None
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