Visuoauditory Associative Memory Established with Cholecystokinin Under Anesthesia Is Retrieved in Behavioral Contexts.
Acoustic Stimulation
Anesthesia
Animals
Association Learning
/ physiology
Auditory Cortex
/ physiology
Cholecystokinin
/ metabolism
Entorhinal Cortex
/ physiology
Male
Memory
/ physiology
Mice
Mice, Inbred C57BL
Neural Pathways
/ physiology
Neuronal Plasticity
/ physiology
Neurons
/ metabolism
Photic Stimulation
Rats
Rats, Sprague-Dawley
Visual Cortex
/ physiology
auditory cortex
cholecystokinin
entorhinal cortex
memory encoding
neural plasticity
operant conditioning
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
04 03 2020
04 03 2020
Historique:
received:
15
07
2019
revised:
26
11
2019
accepted:
27
11
2019
pubmed:
26
1
2020
medline:
1
9
2020
entrez:
26
1
2020
Statut:
ppublish
Résumé
Plastic change in neuronal connectivity is the foundation of memory encoding. It is not clear whether the changes during anesthesia can alter subsequent behavior. Here, we demonstrated that in male rodents under anesthesia, a visual stimulus (VS) was associated with electrical stimulation of the auditory cortex or natural auditory stimulus in the presence of cholecystokinin (CCK), which guided the animals' behavior in a two-choice auditory task. Auditory neurons became responsive to the VS after the pairings. Moreover, high-frequency stimulation of axon terminals of entorhinal CCK neurons in the auditory cortex enabled LTP of the visual response in the auditory cortex. Such pairing during anesthesia also generated VS-induced freezing in an auditory fear conditioning task. Finally, we verified that direct inputs from the entorhinal CCK neurons and the visual cortex enabled the above neural plasticity in the auditory cortex. Our findings suggest that CCK-enabled visuoauditory association during anesthesia can be translated to the subsequent behavior action.
Identifiants
pubmed: 31980587
pii: JNEUROSCI.1673-19.2019
doi: 10.1523/JNEUROSCI.1673-19.2019
pmc: PMC7055132
doi:
Substances chimiques
Cholecystokinin
9011-97-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2025-2037Informations de copyright
Copyright © 2020 Zhang et al.
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