PTH induces bone loss via microbial-dependent expansion of intestinal TNF

Animals Fecal Microbiota Transplantation Female Gastrointestinal Microbiome / immunology Germ-Free Life Gram-Positive Endospore-Forming Rods / immunology Hyperparathyroidism, Primary / complications Intestines / immunology Mice Mice, Inbred C57BL Mice, Knockout Osteoporosis / etiology Parathyroid Hormone / immunology T-Lymphocyte Subsets / immunology Th17 Cells / immunology Tumor Necrosis Factor-alpha / immunology

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
24 01 2020
Historique:
received: 05 09 2019
accepted: 19 12 2019
entrez: 26 1 2020
pubmed: 26 1 2020
medline: 14 4 2020
Statut: epublish

Résumé

Bone loss is a frequent but not universal complication of hyperparathyroidism. Using antibiotic-treated or germ-free mice, we show that parathyroid hormone (PTH) only caused bone loss in mice whose microbiota was enriched by the Th17 cell-inducing taxa segmented filamentous bacteria (SFB). SFB

Identifiants

DOI: 10.1038/s41467-019-14148-4 PMID: 31980603 PMC: PMC6981196
pubmed: 31980603
doi: 10.1038/s41467-019-14148-4
pii: 10.1038/s41467-019-14148-4
pmc: PMC6981196
doi:

Substances chimiques

Parathyroid Hormone 0
Tumor Necrosis Factor-alpha 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

468

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK112946
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR028009
Pays : United States
Organisme : NIA NIH HHS
ID : U54 AG062334
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124821
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK119229
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK108842
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR068157
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR070091
Pays : United States
Organisme : BLRD VA
ID : I01 BX000105
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK098391
Pays : United States

Commentaires et corrections

Type : CommentIn

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Auteurs

Mingcan Yu (M)

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Emory Microbiome Research Center, Emory University, Atlanta, GA, USA.

Abdul Malik Tyagi (A)

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Emory Microbiome Research Center, Emory University, Atlanta, GA, USA.

Jau-Yi Li (JY)

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Emory Microbiome Research Center, Emory University, Atlanta, GA, USA.

Jonathan Adams (J)

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Emory Microbiome Research Center, Emory University, Atlanta, GA, USA.

Timothy L Denning (TL)

Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.

M Neale Weitzmann (MN)

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Emory Microbiome Research Center, Emory University, Atlanta, GA, USA.
Atlanta VA Medical Center, Decatur, GA, USA.

Rheinallt M Jones (RM)

Emory Microbiome Research Center, Emory University, Atlanta, GA, USA.
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Emory University, Atlanta, GA, USA.
Immunology and Molecular Pathogenesis Program, Emory University, Atlanta, GA, USA.

Roberto Pacifici (R)

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA. roberto.pacifici@emory.edu.
Emory Microbiome Research Center, Emory University, Atlanta, GA, USA. roberto.pacifici@emory.edu.
Immunology and Molecular Pathogenesis Program, Emory University, Atlanta, GA, USA. roberto.pacifici@emory.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › PTH induces bone loss via microbial-dependent...
questionsmedicales.fr › Thérapeutique › Biothérapie › Transplantation de microbiote fécal › PTH induces bone loss via microbial-dependent...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › PTH induces bone loss via microbial-dependent...
questionsmedicales.fr › Phénomènes microbiologiques › Axénie › PTH induces bone loss via microbial-dependent...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › PTH induces bone loss via microbial-dependent...
questionsmedicales.fr › Maladies endocriniennes › Maladies de la parathyroïde › Hyperparathyroïdie › Hyperparathyroïdie primitive › PTH induces bone loss via microbial-dependent...
questionsmedicales.fr › Système digestif › Tube digestif › Intestins › PTH induces bone loss via microbial-dependent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › PTH induces bone loss via microbial-dependent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › PTH induces bone loss via microbial-dependent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › PTH induces bone loss via microbial-dependent...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Maladies osseuses métaboliques › Ostéoporose › PTH induces bone loss via microbial-dependent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormone parathyroïdienne › PTH induces bone loss via microbial-dependent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › PTH induces bone loss via microbial-dependent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Cellules Th17 › PTH induces bone loss via microbial-dependent...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › PTH induces bone loss via microbial-dependent...