Chimeric antigen receptor T-cell therapy for multiple myeloma.
Chimeric antigen receptor
Integrin
Multiple myeloma
Protein conformation
T cell
Journal
International journal of hematology
ISSN: 1865-3774
Titre abrégé: Int J Hematol
Pays: Japan
ID NLM: 9111627
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
20
08
2019
accepted:
15
01
2020
pubmed:
26
1
2020
medline:
9
9
2020
entrez:
26
1
2020
Statut:
ppublish
Résumé
Chimeric antigen receptor (CAR) T cell therapy, an immunotherapy using gene-modified T cells, has recently made a big success. CAR T cells targeting CD19 is highly effective against B cell malignancies. Next good target for CAR T therapy is multiple myeloma. B cell maturation antigen has been proved to be a good target for CAR T cell therapy in early-phase clinical trials. We are also developing CAR T cells targeting a protein conformation that is preferentially detected in myeloma cells. In this review, I will summarize the state of art in the field of CAR T cell therapy against myeloma, and also present our effort to develop a new CAR T cell therapy.
Identifiants
pubmed: 31981097
doi: 10.1007/s12185-020-02827-8
pii: 10.1007/s12185-020-02827-8
doi:
Substances chimiques
Antigens, CD19
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
530-534Références
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