Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.
Animals
Antiviral Agents
/ adverse effects
Cytomegalovirus
/ drug effects
Cytomegalovirus Infections
/ immunology
Cytomegalovirus Vaccines
/ therapeutic use
Drug Resistance, Viral
Foscarnet
/ therapeutic use
Ganciclovir
/ therapeutic use
Hematopoietic Stem Cell Transplantation
/ adverse effects
Humans
Immunocompromised Host
Immunosuppressive Agents
/ adverse effects
Immunotherapy
/ adverse effects
Immunotherapy, Adoptive
/ trends
Molecular Targeted Therapy
/ adverse effects
Opportunistic Infections
/ immunology
Risk Factors
T-Lymphocytes
/ immunology
Treatment Outcome
Antiviral
Cytomegalovirus
Filociclovir
Hematopoietic cell transplant
Letermovir
Maribavir
Journal
Current hematologic malignancy reports
ISSN: 1558-822X
Titre abrégé: Curr Hematol Malig Rep
Pays: United States
ID NLM: 101262565
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
pubmed:
26
1
2020
medline:
22
12
2020
entrez:
26
1
2020
Statut:
ppublish
Résumé
CMV DNA polymerase inhibitors such as ganciclovir and foscarnet have dramatically reduced the burden of CMV infection in the HCT recipient. However, their use is often limited by toxicities and resistance. Agents with novel mechanisms and favorable toxicity profiles are critically needed. We review recent developments in CMV antivirals and immune-based approaches to mitigating CMV infection. Letermovir, an inhibitor of the CMV terminase complex, was approved in 2017 for primary CMV prophylaxis in adult seropositive allogeneic HCT recipients. Maribavir, an inhibitor of the CMV UL97 kinase, is currently in two phase 3 treatment studies. Adoptive immunotherapy using third-party T cells has proven safe and effective in preliminary studies. Vaccine development continues, with several promising candidates currently under study. No longer limited to DNA polymerase inhibitors, the prevention and treatment of CMV infections in the HCT recipient is a rapidly evolving field which should translate into improvements in CMV-related outcomes.
Identifiants
pubmed: 31981100
doi: 10.1007/s11899-020-00557-6
pii: 10.1007/s11899-020-00557-6
pmc: PMC7223398
doi:
Substances chimiques
Antiviral Agents
0
Cytomegalovirus Vaccines
0
Immunosuppressive Agents
0
Foscarnet
364P9RVW4X
Ganciclovir
P9G3CKZ4P5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
90-102Références
J Antimicrob Chemother. 2020 Mar 1;75(3):775-777
pubmed: 31800049
Antimicrob Agents Chemother. 2015 Oct;59(10):6588-93
pubmed: 26259791
Antimicrob Agents Chemother. 2012 Jan;56(1):197-201
pubmed: 21968367
Blood. 2013 Jun 27;121(26):5113-23
pubmed: 23610374
J Infect Dis. 2017 Nov 15;216(8):926-928
pubmed: 29029104
Antimicrob Agents Chemother. 2002 Aug;46(8):2373-80
pubmed: 12121907
Antimicrob Agents Chemother. 2013 Jul;57(7):3375-9
pubmed: 23650173
Antimicrob Agents Chemother. 2004 Nov;48(11):4154-62
pubmed: 15504835
Blood Adv. 2017 Nov 02;1(24):2193-2205
pubmed: 29296867
Lancet. 2003 Oct 25;362(9393):1375-7
pubmed: 14585640
Antiviral Res. 2019 Dec;172:104616
pubmed: 31568799
Haematologica. 1998 Feb;83(2):132-7
pubmed: 9549924
Am J Transplant. 2006 Jan;6(1):69-75
pubmed: 16433758
Blood. 2016 May 19;127(20):2427-38
pubmed: 26884374
Antimicrob Agents Chemother. 2002 Aug;46(8):2381-6
pubmed: 12121908
Intervirology. 1999;42(5-6):412-8
pubmed: 10702725
Virology. 2006 Oct 10;354(1):69-79
pubmed: 16872656
Biochem Biophys Res Commun. 2018 Feb 5;496(2):726-730
pubmed: 29357281
J Virol. 2001 Oct;75(19):9077-86
pubmed: 11533171
Antivir Chem Chemother. 2009 Sep 25;20(1):37-46
pubmed: 19794230
N Engl J Med. 1986 Apr 17;314(16):1006-10
pubmed: 3007984
Am J Transplant. 2009 Oct;9(10):2324-30
pubmed: 19663892
Antimicrob Agents Chemother. 2019 Feb 26;63(3):
pubmed: 30642941
Clin Infect Dis. 2015 Jul 1;61(1):31-9
pubmed: 25778751
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14223-8
pubmed: 14623981
JAMA. 2018 Jul 24;320(4):379-396
pubmed: 30043070
Antimicrob Agents Chemother. 2011 Jan;55(1):382-4
pubmed: 21041510
Transplantation. 1999 Sep 27;68(6):814-25
pubmed: 10515382
Antimicrob Agents Chemother. 2016 Jun 20;60(7):4176-82
pubmed: 27139481
Bone Marrow Transplant. 2020 Apr;55(4):780-786
pubmed: 31664185
Antimicrob Agents Chemother. 2005 Mar;49(3):1039-45
pubmed: 15728900
Transpl Infect Dis. 2019 Dec;21(6):e13187
pubmed: 31585500
J Virol. 2008 Jan;82(1):246-53
pubmed: 17942550
Clin Infect Dis. 2004 Jul 15;39(2):233-9
pubmed: 15307033
J Virol. 2014 May;88(9):4776-85
pubmed: 24522923
Antimicrob Agents Chemother. 2004 May;48(5):1647-51
pubmed: 15105116
Antimicrob Agents Chemother. 2006 Jul;50(7):2557-9
pubmed: 16801445
Antimicrob Agents Chemother. 2010 Mar;54(3):1290-7
pubmed: 20047911
J Virol. 2013 Feb;87(3):1720-32
pubmed: 23175377
Bone Marrow Transplant. 2019 Jun;54(6):911-912
pubmed: 30401966
Biol Blood Marrow Transplant. 2019 Feb;25(2):369-381
pubmed: 30292744
Blood. 2008 Jun 1;111(11):5403-10
pubmed: 18285548
Antimicrob Agents Chemother. 2010 Jun;54(6):2371-8
pubmed: 20385869
J Infect Dis. 2017 Nov 15;216(8):945-956
pubmed: 29029297
J Virol. 1999 Jul;73(7):5663-70
pubmed: 10364316
J Clin Pharmacol. 2007 Feb;47(2):209-17
pubmed: 17244772
J Pediatric Infect Dis Soc. 2020 Sep 17;9(4):486-489
pubmed: 31362308
Antiviral Res. 2018 Oct;158:255-263
pubmed: 30153445
Am J Transplant. 2012 Nov;12(11):3021-30
pubmed: 22947426
J Clin Oncol. 2017 Nov 1;35(31):3547-3557
pubmed: 28783452
Lancet Haematol. 2019 Aug;6(8):e409-e418
pubmed: 31248843
N Engl J Med. 1990 Sep 13;323(11):705-12
pubmed: 2167452
Antimicrob Agents Chemother. 2016 Apr 22;60(5):2881-7
pubmed: 26926639
Blood. 2010 Nov 18;116(20):4360-7
pubmed: 20625005
Biol Blood Marrow Transplant. 2007 Jun;13(6):707-14
pubmed: 17531781
Curr Opin Virol. 2011 Dec;1(6):555-62
pubmed: 22440913
Antimicrob Agents Chemother. 2014;58(4):2329-33
pubmed: 24514084
Blood. 2009 Jun 4;113(23):5711-9
pubmed: 19299333
J Virol. 2011 Oct;85(20):10884-93
pubmed: 21752907
Antimicrob Agents Chemother. 2009 Jan;53(1):81-5
pubmed: 18981262
Antimicrob Agents Chemother. 2015;59(6):3140-8
pubmed: 25779572
Antiviral Res. 2019 Jan;161:116-124
pubmed: 30472161
Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14182-7
pubmed: 16959881
J Clin Pharmacol. 2020 Jan;60(1):96-106
pubmed: 31385617
Am J Transplant. 2018 Dec;18(12):2945-2954
pubmed: 29745007
Lancet Infect Dis. 2011 Apr;11(4):284-92
pubmed: 21414843
Open Forum Infect Dis. 2019 Aug 23;6(9):ofz375
pubmed: 31660414
Antimicrob Agents Chemother. 2004 Dec;48(12):4745-53
pubmed: 15561852
J Infect Dis. 2010 Jul 1;202(1):104-8
pubmed: 20504236
Transpl Infect Dis. 2010 Dec;12(6):489-96
pubmed: 20682012
Bone Marrow Transplant. 1993 Sep;12(3):273-82
pubmed: 8241987
J Virol. 2004 Oct;78(20):11030-9
pubmed: 15452223
Antimicrob Agents Chemother. 2003 Apr;47(4):1334-42
pubmed: 12654667
Blood. 2002 Jun 1;99(11):3916-22
pubmed: 12010789
Antiviral Res. 2017 Dec;148:1-4
pubmed: 29107686
Mediterr J Hematol Infect Dis. 2019 Jan 01;11(1):e2019001
pubmed: 30671207
Bone Marrow Transplant. 1998 Mar;21(5):473-6
pubmed: 9535039
Vaccine. 2019 Nov 28;37(50):7437-7442
pubmed: 29622379
Clin Infect Dis. 2020 Apr 10;70(8):1525-1533
pubmed: 31179485
Clin Infect Dis. 2018 Oct 30;67(10):1477-1492
pubmed: 30215672
Clin Infect Dis. 2011 Jan 1;52(1):49-57
pubmed: 21148519
Ann Intern Med. 1987 Jan;106(1):12-8
pubmed: 3024542
Antimicrob Agents Chemother. 2019 Aug 23;63(9):
pubmed: 31285228
Antimicrob Agents Chemother. 2010 Aug;54(8):3093-8
pubmed: 20547817
Transplantation. 2010 Aug 27;90(4):419-26
pubmed: 20683281
J Exp Med. 2005 Sep 5;202(5):673-85
pubmed: 16147978
Antiviral Res. 2008 Jul;79(1):49-61
pubmed: 18329738
Clin Microbiol Rev. 2010 Oct;23(4):689-712
pubmed: 20930070
Antimicrob Agents Chemother. 2011 Oct;55(10):4682-91
pubmed: 21788463
J Virol. 2017 May 26;91(12):
pubmed: 28356534
J Infect Dis. 1991 Sep;164(3):483-7
pubmed: 1651360
J Virol. 2004 Jul;78(13):7124-30
pubmed: 15194788
J Infect Dis. 2002 Feb 1;185(3):273-82
pubmed: 11807708
Clin Infect Dis. 2008 May 1;46(9):1455-7
pubmed: 18419454
Blood. 2008 Nov 15;112(10):3974-81
pubmed: 18768783
Am J Transplant. 2020 Jun;20(6):1703-1711
pubmed: 31883426
Antiviral Res. 2011 Jun;90(3):183-6
pubmed: 21443904
N Engl J Med. 2019 Sep 19;381(12):1136-1147
pubmed: 31532960
Clin Infect Dis. 2019 Apr 8;68(8):1255-1264
pubmed: 30329038
Antimicrob Agents Chemother. 2017 Oct 24;61(11):
pubmed: 28827420
Blood. 2007 Jul 15;110(2):490-500
pubmed: 17392502
Haematologica. 2014 Oct;99(10):1624-31
pubmed: 25085357
BMC Infect Dis. 2019 May 8;19(1):388
pubmed: 31068147
Blood Cells Mol Dis. 2008 Jan-Feb;40(1):63-7
pubmed: 17869548
J Virol. 2003 Nov;77(21):11499-506
pubmed: 14557635
Blood. 2013 Nov 7;122(19):3359-64
pubmed: 24037724
Am J Transplant. 2018 Dec;18(12):3060-3064
pubmed: 30286286
Sci Transl Med. 2016 Oct 26;8(362):362ra145
pubmed: 27797961
N Engl J Med. 2014 May 8;370(19):1781-9
pubmed: 24806159
Ann Intern Med. 1988 Nov 15;109(10):783-8
pubmed: 2847610
Clin Pharmacol Drug Dev. 2018 Jan;7(1):9-21
pubmed: 28967706
Antiviral Res. 2019 Mar;163:91-105
pubmed: 30690043
Ann Intern Med. 1988 Nov 15;109(10):777-82
pubmed: 2847609
Antimicrob Agents Chemother. 2003 Jul;47(7):2186-92
pubmed: 12821466
Expert Rev Vaccines. 2018 Oct;17(10):889-911
pubmed: 30246580
Pharmacotherapy. 2010 Jun;30(6):554-61
pubmed: 20500045
N Engl J Med. 1995 Oct 19;333(16):1038-44
pubmed: 7675046
J Infect Dis. 2007 Jul 1;196(1):91-4
pubmed: 17538888
J Virol. 2019 Nov 13;93(23):
pubmed: 31511385
Antiviral Res. 2016 Oct;134:130-143
pubmed: 27515131
Clin Transl Sci. 2017 Nov;10(6):487-495
pubmed: 28675594
J Infect Dis. 2020 Mar 16;221(7):1117-1126
pubmed: 31781762
Rev Med Virol. 2009 Jul;19(4):215-29
pubmed: 19434630
Rev Med Virol. 2002 Mar-Apr;12(2):115-27
pubmed: 11921307
N Engl J Med. 2013 Sep 26;369(13):1227-36
pubmed: 24066743
Antimicrob Agents Chemother. 2006 Apr;50(4):1130-5
pubmed: 16569820
J Clin Pharmacol. 2018 Jul;58(7):897-904
pubmed: 29578577
Bone Marrow Transplant. 1994 Feb;13(2):163-7
pubmed: 8205085
Bone Marrow Transplant. 1997 Feb;19(3):233-6
pubmed: 9028551
Science. 1992 Jul 10;257(5067):238-41
pubmed: 1352912
Antimicrob Agents Chemother. 2002 Aug;46(8):2365-72
pubmed: 12121906
Rev Med Virol. 2008 Jul-Aug;18(4):233-46
pubmed: 18383425
Blood. 2013 May 2;121(18):3745-58
pubmed: 23435462
Antimicrob Agents Chemother. 2012 Feb;56(2):1135-7
pubmed: 22106211
J Med Chem. 2004 Jan 29;47(3):566-75
pubmed: 14736238
Lancet Infect Dis. 2011 Apr;11(4):255-7
pubmed: 21414844
Antimicrob Agents Chemother. 2002 Sep;46(9):2969-76
pubmed: 12183255
J Infect Dis. 2019 Jul 2;220(3):411-419
pubmed: 31535143
Br J Clin Pharmacol. 2017 Sep;83(9):1944-1953
pubmed: 28345163
PLoS Pathog. 2009 Jan;5(1):e1000275
pubmed: 19165338
Biochem Pharmacol. 2011 Jan 1;81(1):43-9
pubmed: 20846508
N Engl J Med. 2017 Dec 21;377(25):2433-2444
pubmed: 29211658
Antimicrob Agents Chemother. 2014;58(1):610-3
pubmed: 24189264
J Infect Dis. 2016 Jan 1;213(1):23-30
pubmed: 26113373
J Clin Virol. 2006 Oct;37(2):124-7
pubmed: 16962820
J Clin Pharmacol. 2019 Oct;59(10):1331-1339
pubmed: 30990905
Am J Transplant. 2010 May;10(5):1228-37
pubmed: 20353469
Br J Clin Pharmacol. 2017 Dec;83(12):2678-2686
pubmed: 28722153
Biol Blood Marrow Transplant. 2001;7(6):343-51
pubmed: 11464977
Clin Infect Dis. 2008 Sep 15;47(6):804-11
pubmed: 18699744