Prospective Associations Between Diffusion Tensor Imaging Parameters and Frailty in Older Adults.
brain health
diffusion magnetic resonance imagingfrailty
physical capacity
Journal
Journal of the American Geriatrics Society
ISSN: 1532-5415
Titre abrégé: J Am Geriatr Soc
Pays: United States
ID NLM: 7503062
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
16
09
2019
revised:
18
12
2019
accepted:
18
12
2019
pubmed:
26
1
2020
medline:
20
2
2021
entrez:
26
1
2020
Statut:
ppublish
Résumé
Cross-sectional associations have been found between frail individuals and worse white matter (WM) integrity. However, the prospective association between WM integrity and frailty is still unclear. Our objectives were to measure associations between WM integrity using diffusion tensor imaging (DTI) and the 5-year worsening of frailty in community-dwelling older adults. Secondary analysis of the randomized controlled Multidomain Alzheimer Preventive Trial (MAPT). Thirteen memory centers in France and Monaco between 2008 and 2011. Participants (mean age = 74.7 ± 3.9 years) with no dementia at baseline who had functional magnetic resonance imaging performed as part of the MAPT study (n = 227). Fractional anisotropy and mean diffusivity (MD), axial diffusivity (AxD), and radial diffusivity (RD) were acquired for 10 different brain regions. Frailty was assessed by the Fried frailty phenotype (score from 0 to 5, higher is worse) at up to seven time points for 5 years. Mixed effect ordinal logistic regression model was used to assess the prospective association between DTI parameters (independent variables) and frailty (dependent variable). All the analyses were adjusted for age, sex, baseline total intracranial volume, and the presence of one of the following cardiovascular risk factors (hypertension, diabetes, and/or hypercholesterolemia). A statistically significant association was found between the RD, AxD, and MD for different brain regions (anterior limb of internal capsule, external capsule, posterior corona radiata, posterior thalamic radiation, superior corona radiata, superior frontal occipital fasciculus, and superior longitudinal fasciculus) and worsening of frailty over 5 years after adjusting for multiple comparisons. This is the first study to show that WM integrity is associated with frailty in older adults. The mechanisms related to these results require further investigation. J Am Geriatr Soc 68:1050-1055, 2020.
Sections du résumé
BACKGROUND
Cross-sectional associations have been found between frail individuals and worse white matter (WM) integrity. However, the prospective association between WM integrity and frailty is still unclear. Our objectives were to measure associations between WM integrity using diffusion tensor imaging (DTI) and the 5-year worsening of frailty in community-dwelling older adults.
DESIGN
Secondary analysis of the randomized controlled Multidomain Alzheimer Preventive Trial (MAPT).
SETTING
Thirteen memory centers in France and Monaco between 2008 and 2011.
PARTICIPANTS
Participants (mean age = 74.7 ± 3.9 years) with no dementia at baseline who had functional magnetic resonance imaging performed as part of the MAPT study (n = 227).
MEASUREMENTS
Fractional anisotropy and mean diffusivity (MD), axial diffusivity (AxD), and radial diffusivity (RD) were acquired for 10 different brain regions. Frailty was assessed by the Fried frailty phenotype (score from 0 to 5, higher is worse) at up to seven time points for 5 years. Mixed effect ordinal logistic regression model was used to assess the prospective association between DTI parameters (independent variables) and frailty (dependent variable). All the analyses were adjusted for age, sex, baseline total intracranial volume, and the presence of one of the following cardiovascular risk factors (hypertension, diabetes, and/or hypercholesterolemia).
RESULTS
A statistically significant association was found between the RD, AxD, and MD for different brain regions (anterior limb of internal capsule, external capsule, posterior corona radiata, posterior thalamic radiation, superior corona radiata, superior frontal occipital fasciculus, and superior longitudinal fasciculus) and worsening of frailty over 5 years after adjusting for multiple comparisons.
CONCLUSIONS
This is the first study to show that WM integrity is associated with frailty in older adults. The mechanisms related to these results require further investigation. J Am Geriatr Soc 68:1050-1055, 2020.
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1050-1055Investigateurs
Bruno Vellas
(B)
Sophie Guyonnet
(S)
Isabelle Carrié
(I)
Lauréane Brigitte
(L)
Catherine Faisant
(C)
Françoise Lala
(F)
Julien Delrieu
(J)
Hélène Villars
(H)
Emeline Combrouze
(E)
Carole Badufle
(C)
Audrey Zueras
(A)
Sandrine Andrieu
(S)
Christelle Cantet
(C)
Christophe Morin
(C)
Gabor Abellan Van Kan
(GA)
Charlotte Dupuy
(C)
Yves Rolland
(Y)
Céline Caillaud
(C)
Pierre-Jean Ousset
(PJ)
Françoise Lala
(F)
Jean-François Dartigues
(JF)
Isabelle Marcet
(I)
Fleur Delva
(F)
Alexandra Foubert
(A)
Sandrine Cerda
(S)
None Marie-Noëlle-Cuffi
Corinne Costes
(C)
Olivier Rouaud
(O)
Patrick Manckoundia
(P)
Valérie Quipourt
(V)
Sophie Marilier
(S)
Evelyne Franon
(E)
Lawrence Bories
(L)
Marie-Laure Pader
(ML)
Marie-France Basset
(MF)
Bruno Lapoujade
(B)
Valérie Faure
(V)
Michael LiYungTong
(M)
Christine Malick-Loiseau
(C)
Evelyne Cazaban-Campistron
(E)
Françoise Desclaux
(F)
Colette Blatge
(C)
Thierry Dantoine
(T)
Cécile Laubarie-Mouret
(C)
Isabelle Saulnier
(I)
Jean-Pierre Clément
(JP)
Marie-Agnès Picat
(MA)
Laurence Bernard-Bourzeix
(L)
Stéphanie Willebois
(S)
Iléana Désormais
(I)
Noëlle Cardinaud
(N)
Marc Bonnefoy
(M)
Pierre Livet
(P)
Pascale Rebaudet
(P)
Claire Gédéon
(C)
Catherine Burdet
(C)
Flavien Terracol
(F)
Alain Pesce
(A)
Stéphanie Roth
(S)
Sylvie Chaillou
(S)
Sandrine Louchart
(S)
Kristelle Sudres
(K)
Nicolas Lebrun
(N)
Nadège Barro-Belaygues
(N)
Jacques Touchon
(J)
Karim Bennys
(K)
Audrey Gabelle
(A)
Aurélia Romano
(A)
Lynda Touati
(L)
Cécilia Marelli
(C)
Cécile Pays
(C)
Philippe Robert
(P)
Franck Le Duff
(F)
Claire Gervais
(C)
Sébastien Gonfrier
(S)
Yannick Gasnier
(Y)
Serge Bordes
(S)
Danièle Begorre
(D)
Christian Carpuat
(C)
Khaled Khales
(K)
Jean-François Lefebvre
(JF)
Samira Misbah El Idrissi
(S)
Pierre Skolil
(P)
Jean-Pierre Salles
(JP)
Carole Dufouil
(C)
Stéphane Lehéricy
(S)
Marie Chupin
(M)
Jean-François Mangin
(JF)
Ali Bouhayia
(A)
Michèle Allard
(M)
Frédéric Ricolfi
(F)
Dominique Dubois
(D)
Marie Paule Bonceour Martel
(MPB)
François Cotton
(F)
Alain Bonafé
(A)
Stéphane Chanalet
(S)
Françoise Hugon
(F)
Fabrice Bonneville
(F)
Christophe Cognard
(C)
François Chollet
(F)
Pierre Payoux
(P)
Thierry Voisin
(T)
Julien Delrieu
(J)
Sophie Peiffer
(S)
Anne Hitzel
(A)
Michèle Allard
(M)
Michel Zanca
(M)
Jacques Monteil
(J)
Jacques Darcourt
(J)
Laurent Molinier
(L)
Hélène Derumeaux
(H)
Nadège Costa
(N)
Bertrand Perret
(B)
Claire Vinel
(C)
Sylvie Caspar-Bauguil
(S)
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The American Geriatrics Society.
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