Effects of acute versus recurrent insulin-induced hypoglycemia on ventromedial hypothalamic nucleus metabolic-sensory neuron AMPK activity: Impact of alpha
Aspartate
Neuronal nitric oxide synthase
Prazocin
Recurrent insulin-induced hypoglycemia
Ventromedial hypothalamic nucleus
Journal
Brain research bulletin
ISSN: 1873-2747
Titre abrégé: Brain Res Bull
Pays: United States
ID NLM: 7605818
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
14
05
2019
revised:
15
12
2019
accepted:
17
01
2020
pubmed:
26
1
2020
medline:
18
8
2021
entrez:
26
1
2020
Statut:
ppublish
Résumé
Mechanisms that underlie metabolic sensor acclimation to recurring insulin-induced hypoglycemia (RIIH) are unclear. Norepinephrine (NE) regulates ventromedial hypothalamic nucleus (VMN) gluco-stimulatory nitric oxide (NO) and gluco-inhibitory γ-aminobutryic acid (GABA) neuron signaling. Current research addressed the hypothesis that during RIIH, NE suppresses 5'-AMP-activated protein kinase (AMPK) reactivity in both populations and impedes counter-regulation. The brain is postulated to utilize non-glucose substrates, e.g. amino acids glutamine (Gln), glutamate (Glu), and aspartate (Asp), to produce energy during hypoglycemia. A correlated aim investigated whether NE controls pyruvate recycling pathway marker protein (glutaminase, GLT; malic enzyme, ME-1) expression in either metabolic-sensory cell population. Male rats were injected subcutaneously with vehicle or insulin on days 1-3, then pretreated on day 4 by intracerebroventricular delivery of the alpha
Identifiants
pubmed: 31981674
pii: S0361-9230(19)30375-2
doi: 10.1016/j.brainresbull.2020.01.013
pmc: PMC7332013
mid: NIHMS1556843
pii:
doi:
Substances chimiques
Hypoglycemic Agents
0
Insulin
0
Receptors, Estrogen
0
AMP-Activated Protein Kinases
EC 2.7.11.31
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-50Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK109382
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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