Plasma pharmacokinetic and metabolism of [
(S)-[(18)F]THK-5117
Metabolism
Pharmacokinetic
Sex-dependent
[(18)F]THK-5317
Journal
Nuclear medicine and biology
ISSN: 1872-9614
Titre abrégé: Nucl Med Biol
Pays: United States
ID NLM: 9304420
Informations de publication
Date de publication:
Historique:
received:
14
10
2019
revised:
08
01
2020
accepted:
12
01
2020
pubmed:
26
1
2020
medline:
14
7
2021
entrez:
26
1
2020
Statut:
ppublish
Résumé
Tau deposition is one of the hallmarks of Alzheimer's disease (AD) and can be visualized and quantified using [ Female and male rats (n = 11-12) were cannulated via the femoral artery for continuous blood sampling. Blood sampling was performed at regular intervals after intravenous injection of [ Plasma pharmacokinetics and metabolism were significantly different between female and male rats. [ Our results show pronounced sex differences in blood/plasma pharmacokinetics and metabolism of [ First preclinical study in rats showing pronounced sex differences in blood/plasma pharmacokinetics and metabolism of [ Sex-specific differences might also be present in humans and thus clinical trials should have adequate sample size to account for effects in men and women separately.
Identifiants
pubmed: 31981857
pii: S0969-8051(19)30518-9
doi: 10.1016/j.nucmedbio.2020.01.001
pii:
doi:
Substances chimiques
6-((3-fluoro-2-hydroxy)propoxy)-2-(4-methylaminophenyl)quinoline
0
Aniline Compounds
0
Quinolines
0
Radioactive Tracers
0
tau Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
28-32Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.