Steroidal saponins from Trillium tschonoskii rhizomes and their cytotoxicity against HepG2 cells.
Antineoplastic Agents, Phytogenic
/ chemistry
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Hep G2 Cells
Humans
Molecular Conformation
Plant Extracts
/ chemistry
Saponins
/ chemistry
Stereoisomerism
Steroids
/ chemistry
Structure-Activity Relationship
Trillium
/ chemistry
HepG2 cell
Liliaceae
Steroidal saponin
Trillitschoside
Trillium tschonoskii
Journal
Steroids
ISSN: 1878-5867
Titre abrégé: Steroids
Pays: United States
ID NLM: 0404536
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
14
06
2019
revised:
02
01
2020
accepted:
20
01
2020
pubmed:
27
1
2020
medline:
5
2
2021
entrez:
27
1
2020
Statut:
ppublish
Résumé
A phytochemical study on the rhizomes of Trillium tschonoskii led to the isolation of fourteen new steroidal saponins, trillitschosides S1-S14 (1-14), along with ten known analogues (15-24). Their structures were established mainly by spectroscopic analyses as well as necessary chemical evidence. All isolated compounds were screened for the cytotoxicity against HepG2 cells, and the results demonstrated that only the known compounds 21-24 exhibited the remarkable cytotoxic activity against HepG2 cells which is much better than the positive control of 5-FU.
Identifiants
pubmed: 31982423
pii: S0039-128X(20)30012-X
doi: 10.1016/j.steroids.2020.108587
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Plant Extracts
0
Saponins
0
Steroids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108587Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.