Enhanced cognitive performance in experimental autoimmune encephalomyelitis mice treated with dimethyl fumarate after the appearance of disease symptoms.
Autoimmunity
Cognition
Dimethyl fumarate
Experimental autoimmune encephalomyelitis
Multiple sclerosis
Rodent
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 03 2020
15 03 2020
Historique:
received:
21
08
2019
revised:
02
01
2020
accepted:
10
01
2020
pubmed:
27
1
2020
medline:
29
8
2020
entrez:
27
1
2020
Statut:
ppublish
Résumé
In multiple sclerosis (MS), cognitive dysfunction is common but difficult to treat. We analyzed the impact of dimethyl fumarate, an MS drug with neuroprotective properties, in spatial memory performance in a mouse model of MS and looked for structural correlates in the hippocampus. Treated mice presented better cognitive performance which was not associated with structural hippocampal damage but with decreased demyelination in the fimbria. Dimethyl fumarate, even if initiated after hindlimb paralysis, ameliorated memory deficits in the MS mouse model due, at least in part, to its positive impact in the demyelination of the main hippocampal output pathway.
Identifiants
pubmed: 31982706
pii: S0165-5728(19)30376-5
doi: 10.1016/j.jneuroim.2020.577163
pii:
doi:
Substances chimiques
Neuroprotective Agents
0
Dimethyl Fumarate
FO2303MNI2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
577163Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest This work was funded by an investigator initiated grant from Biogen to João J. Cerqueira (PRT-BGT-13-10438).