Lithium prevents grey matter atrophy in patients with bipolar disorder: an international multicenter study.
Adult
Antimanic Agents
/ therapeutic use
Atrophy
/ prevention & control
Bipolar Disorder
/ drug therapy
Case-Control Studies
Female
Gray Matter
/ pathology
Gyrus Cinguli
/ pathology
Hippocampus
/ pathology
Humans
Lithium Compounds
/ therapeutic use
Magnetic Resonance Imaging
Male
Middle Aged
Temporal Lobe
/ pathology
Bipolar disorder
MRI
grey matter volume
lithium
Journal
Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
pubmed:
28
1
2020
medline:
1
12
2021
entrez:
28
1
2020
Statut:
ppublish
Résumé
Lithium (Li) is the gold standard treatment for bipolar disorder (BD). However, its mechanisms of action remain unknown but include neurotrophic effects. We here investigated the influence of Li on cortical and local grey matter (GM) volumes in a large international sample of patients with BD and healthy controls (HC). We analyzed high-resolution T1-weighted structural magnetic resonance imaging scans of 271 patients with BD type I (120 undergoing Li) and 316 HC. Cortical and local GM volumes were compared using voxel-wise approaches with voxel-based morphometry and SIENAX using FSL. We used multiple linear regression models to test the influence of Li on cortical and local GM volumes, taking into account potential confounding factors such as a history of alcohol misuse. Patients taking Li had greater cortical GM volume than patients without. Patients undergoing Li had greater regional GM volumes in the right middle frontal gyrus, the right anterior cingulate gyrus, and the left fusiform gyrus in comparison with patients not taking Li. Our results in a large multicentric sample support the hypothesis that Li could exert neurotrophic and neuroprotective effects limiting pathological GM atrophy in key brain regions associated with BD.
Sections du résumé
BACKGROUND
Lithium (Li) is the gold standard treatment for bipolar disorder (BD). However, its mechanisms of action remain unknown but include neurotrophic effects. We here investigated the influence of Li on cortical and local grey matter (GM) volumes in a large international sample of patients with BD and healthy controls (HC).
METHODS
We analyzed high-resolution T1-weighted structural magnetic resonance imaging scans of 271 patients with BD type I (120 undergoing Li) and 316 HC. Cortical and local GM volumes were compared using voxel-wise approaches with voxel-based morphometry and SIENAX using FSL. We used multiple linear regression models to test the influence of Li on cortical and local GM volumes, taking into account potential confounding factors such as a history of alcohol misuse.
RESULTS
Patients taking Li had greater cortical GM volume than patients without. Patients undergoing Li had greater regional GM volumes in the right middle frontal gyrus, the right anterior cingulate gyrus, and the left fusiform gyrus in comparison with patients not taking Li.
CONCLUSIONS
Our results in a large multicentric sample support the hypothesis that Li could exert neurotrophic and neuroprotective effects limiting pathological GM atrophy in key brain regions associated with BD.
Identifiants
pubmed: 31983348
doi: 10.1017/S0033291719004112
pii: S0033291719004112
doi:
Substances chimiques
Antimanic Agents
0
Lithium Compounds
0
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1201-1210Subventions
Organisme : NIMH NIH HHS
ID : R01 MH076971
Pays : United States