Unusual Two-Step Assembly of a Minimalistic Dipeptide-Based Functional Hypergelator.
Biocompatible Materials
/ chemistry
Cell Adhesion
Cell Proliferation
DNA
/ chemistry
Dipeptides
/ chemistry
Electric Conductivity
Hydrogels
/ chemistry
Hydrogen Bonding
Hydrophobic and Hydrophilic Interactions
Mechanical Phenomena
Molecular Dynamics Simulation
Molecular Structure
Protein Multimerization
Structure-Activity Relationship
Surface Properties
conductive composites
dipeptide
molecular dynamics
self-assembly
two-step gelation
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
15
09
2019
revised:
03
12
2019
pubmed:
28
1
2020
medline:
18
12
2020
entrez:
28
1
2020
Statut:
ppublish
Résumé
Self-assembled peptide hydrogels represent the realization of peptide nanotechnology into biomedical products. There is a continuous quest to identify the simplest building blocks and optimize their critical gelation concentration (CGC). Herein, a minimalistic, de novo dipeptide, Fmoc-Lys(Fmoc)-Asp, as an hydrogelator with the lowest CGC ever reported, almost fourfold lower as compared to that of a large hexadecapeptide previously described, is reported. The dipeptide self-assembles through an unusual and unprecedented two-step process as elucidated by solid-state NMR and molecular dynamics simulation. The hydrogel is cytocompatible and supports 2D/3D cell growth. Conductive composite gels composed of Fmoc-Lys(Fmoc)-Asp and a conductive polymer exhibit excellent DNA binding. Fmoc-Lys(Fmoc)-Asp exhibits the lowest CGC and highest mechanical properties when compared to a library of dipeptide analogues, thus validating the uniqueness of the molecular design which confers useful properties for various potential applications.
Identifiants
pubmed: 31984580
doi: 10.1002/adma.201906043
doi:
Substances chimiques
Biocompatible Materials
0
Dipeptides
0
Hydrogels
0
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1906043Subventions
Organisme : National Key Research and Development Program of China
ID : 2016YFA0501702
Organisme : National Science Foundation of China
ID : 11674065
Organisme : European Research Council under the European Union's Horizon 2020 research and innovation program
ID : 694426
Organisme : Tel Aviv University
Organisme : Center for Nanoscience and Nanotechnology of Tel Aviv University
Informations de copyright
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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