A sticky proposition: The endothelial glycocalyx and von Willebrand factor.
cellular mechanotransduction
endothelial cells
glycocalyx
hemostasis
von Willebrand factor
Journal
Journal of thrombosis and haemostasis : JTH
ISSN: 1538-7836
Titre abrégé: J Thromb Haemost
Pays: England
ID NLM: 101170508
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
26
11
2019
revised:
10
01
2020
accepted:
14
01
2020
pubmed:
28
1
2020
medline:
15
5
2021
entrez:
28
1
2020
Statut:
ppublish
Résumé
Von Willebrand factor (VWF) is a critical component of the hemostatic system. Basal secretion of VWF from endothelial cells is the principal determinant of an individual's baseline plasma VWF levels, while endothelial VWF release can also be induced by several biochemical agonists and biomechanical forces such as increased shear stress. However, the mechanotransduction machinery responsible for this latter response is unclear. Here we propose that the endothelial glycocalyx (EGC), a dynamic layer of proteins and carbohydrates that covers the surface of the vascular endothelium, may play a key role in mediating this response. The EGC has previously been implicated in mediating the mechanotransduction of shear stress in other shear-responsive endothelial processes, such as nitric oxide production and stem cell differentiation. Here, we hypothesize that a similar mechanism may be responsible for the basal secretion of endothelial VWF, whereby the EGC mediates the mechanotransduction of physiological shear stress generated by flowing blood, that in turn contributes to the maintenance of physiological plasma VWF levels.
Identifiants
pubmed: 31984614
doi: 10.1111/jth.14743
pmc: PMC7594466
mid: NIHMS1639379
pii: S1538-7836(22)00288-4
doi:
Substances chimiques
von Willebrand Factor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
781-785Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL144457
Pays : United States
Informations de copyright
© 2020 International Society on Thrombosis and Haemostasis.
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