Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA.

Amino Acid Sequence Animals Binding Sites Conotoxins / chemical synthesis Disulfides / chemistry Humans Mice Molecular Docking Simulation Nicotinic Antagonists / chemistry Protein Binding Rats Receptors, Nicotinic / chemistry

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
27 02 2020
Historique:
pubmed: 28 1 2020
medline: 1 9 2020
entrez: 28 1 2020
Statut: ppublish

Résumé

αO-conotoxin GeXIVA from

Identifiants

DOI: 10.1021/acs.jmedchem.9b01409 PMID: 31986036
pubmed: 31986036
doi: 10.1021/acs.jmedchem.9b01409
doi:

Substances chimiques

CHRNA10 protein, human 0
CHRNA9 protein, human 0
Chrna10 protein, rat 0
Chrna9 protein, rat 0
Conotoxins 0
Disulfides 0
Nicotinic Antagonists 0
Receptors, Nicotinic 0
alpha-conotoxin, Conus generalis 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1564-1575

Auteurs

Pan Xu (P)

Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences , Hainan University , Haikou 570228 , China.

Quentin Kaas (Q)

Institute for Molecular Bioscience , The University of Queensland , Brisbane , Queensland 4072 , Australia.
ORCID: 0000-0001-9988-6152

Yong Wu (Y)

Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences , Hainan University , Haikou 570228 , China.

Xiaopeng Zhu (X)

Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences , Hainan University , Haikou 570228 , China.

Xincan Li (X)

Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences , Hainan University , Haikou 570228 , China.

Peta J Harvey (PJ)

Institute for Molecular Bioscience , The University of Queensland , Brisbane , Queensland 4072 , Australia.
ORCID: 0000-0003-4735-6242

Dongting Zhangsun (D)

Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences , Hainan University , Haikou 570228 , China.

David J Craik (DJ)

Institute for Molecular Bioscience , The University of Queensland , Brisbane , Queensland 4072 , Australia.
ORCID: 0000-0003-0007-6796

Sulan Luo (S)

Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences , Hainan University , Haikou 570228 , China.
ORCID: 0000-0002-3568-5797

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Structure and Activity Studies of...
questionsmedicales.fr › Eucaryotes › Animaux › Structure and Activity Studies of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Structure and Activity Studies of...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins de mollusque › Conotoxines › Structure and Activity Studies of...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfures › Disulfures › Structure and Activity Studies of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structure and Activity Studies of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Structure and Activity Studies of...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Structure and Activity Studies of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Antagonistes cholinergiques › Antagonistes nicotiniques › Structure and Activity Studies of...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Structure and Activity Studies of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Structure and Activity Studies of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteurs nicotiniques › Structure and Activity Studies of...