Copper modulates sex-specific fructose hepatoxicity in nonalcoholic fatty liver disease (NALFD) Wistar rat models.
Animals
Copper
/ metabolism
Copper-Transporting ATPases
/ metabolism
Diet
Disease Models, Animal
Disease Progression
Female
Fructose
/ adverse effects
Liver
/ drug effects
Magnetic Resonance Spectroscopy
Male
Metabolomics
Multivariate Analysis
Non-alcoholic Fatty Liver Disease
/ metabolism
Phenotype
Principal Component Analysis
Rats
Rats, Wistar
Sex Factors
Journal
The Journal of nutritional biochemistry
ISSN: 1873-4847
Titre abrégé: J Nutr Biochem
Pays: United States
ID NLM: 9010081
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
24
07
2019
revised:
07
11
2019
accepted:
06
12
2019
pubmed:
28
1
2020
medline:
24
2
2021
entrez:
28
1
2020
Statut:
ppublish
Résumé
This study aimed to characterize the impact of dietary copper on the biochemical and hepatic metabolite changes associated with fructose toxicity in a Wistar rat model of fructose-induced liver disease. Twenty-four male and 24 female, 6-week-old, Wister rats were separated into four experimental dietary treatment groups (6 males and 6 females per group), as follows: (1) a control diet: containing no fructose with adequate copper (i.e., CuA/0% Fruct); (2) a diet regimen identical to the control and supplemented with 30% w/v fructose in the animals' drinking water (CuA/30% Fruct); (3) a diet identical to the control diet but deficient in copper content (CuD/0% Fruct) and (4) a diet identical to the control diet but deficient in copper content and supplemented with 30% w/v fructose in the drinking water (CuD/30% Fruct). The animals were fed the four diet regimens for 5 weeks, followed by euthanization and assessment of histology, elemental profiles and identification and quantitation of liver metabolites. Results from
Identifiants
pubmed: 31986483
pii: S0955-2863(19)30725-9
doi: 10.1016/j.jnutbio.2019.108316
pmc: PMC7078045
mid: NIHMS1546486
pii:
doi:
Substances chimiques
Fructose
30237-26-4
Copper
789U1901C5
Atp7b protein, rat
EC 7.2.2.8
Copper-Transporting ATPases
EC 7.2.2.8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
108316Subventions
Organisme : NIDDK NIH HHS
ID : R15 DK114747
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR025512
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR026659
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103395
Pays : United States
Organisme : NCRR NIH HHS
ID : P20 RR016466
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Références
Hepatology. 2005 Jun;41(6):1313-21
pubmed: 15915461
Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14219-14224
pubmed: 27911810
World J Hepatol. 2014 May 27;6(5):274-83
pubmed: 24868321
J Hepatol. 2012 Feb;56(2):433-40
pubmed: 21781943
Hepatology. 2010 Jun;51(6):1961-71
pubmed: 20301112
Nucleic Acids Res. 2018 Jul 2;46(W1):W486-W494
pubmed: 29762782
PLoS Biol. 2018 Sep 10;16(9):e2006519
pubmed: 30199530
J Gastroenterol Hepatol. 2015 Jan;30(1):139-46
pubmed: 25040896
Biotechniques. 2007 Jul;43(1 Suppl):25-30
pubmed: 17936939
Nat Chem Biol. 2016 Aug;12(8):586-92
pubmed: 27272565
J Nutr Biochem. 2015 Oct;26(10):996-1006
pubmed: 26033743
J Trace Elem Med Biol. 2017 Jan;39:100-107
pubmed: 27908400
Br J Pharmacol. 2016 Aug;173(15):2352-68
pubmed: 27174364
J Nutr. 2000 Dec;130(12):2915-21
pubmed: 11110846
J Nutr. 1993 Nov;123(11):1939-51
pubmed: 8229312
Am J Gastroenterol. 2010 Sep;105(9):1978-85
pubmed: 20407430
Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19507-12
pubmed: 24218578
Metabolomics. 2015 Aug 1;11(4):895-907
pubmed: 26273237
Food Nutr Res. 2017 Jul 6;61(1):1348866
pubmed: 28747869
J Neurosci Res. 2005 Mar 15;79(6):861-7
pubmed: 15693022
Cell Rep. 2017 Mar 28;18(13):3043-3051
pubmed: 28355557
Physiol Rev. 2009 Jul;89(3):1025-78
pubmed: 19584320
PLoS One. 2013 Aug 30;8(8):e72457
pubmed: 24023619
Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):11-20
pubmed: 28930295
IUBMB Life. 2017 Apr;69(4):263-270
pubmed: 28271632
Clin Gastroenterol Hepatol. 2017 Jan;15(1):127-131.e2
pubmed: 27523635
Anal Biochem. 1997 Nov 15;253(2):169-74
pubmed: 9367499
Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G119-G130
pubmed: 29025734
Ann Nutr Metab. 2007;51(4):301-23
pubmed: 17726308
Medscape J Med. 2008 Jul 09;10(7):160
pubmed: 18769702
J Biol Chem. 2012 Nov 23;287(48):40732-44
pubmed: 23035112
J Gastroenterol. 2011 Jan;46 Suppl 1:63-9
pubmed: 20844903
J Biomol NMR. 2011 Apr;49(3-4):307-23
pubmed: 21360156
J Endocrinol. 2017 Jul;234(1):R1-R21
pubmed: 28428362
Obesity (Silver Spring). 2013 Aug;21(8):1669-75
pubmed: 23512597
Am J Physiol Cell Physiol. 2005 Aug;289(2):C372-8
pubmed: 15800054
Curr Atheroscler Rep. 2005 Nov;7(6):472-9
pubmed: 16256006
Nutrition. 2014 Jul-Aug;30(7-8):928-35
pubmed: 24985013
J Cell Mol Med. 2017 May;21(5):1024-1032
pubmed: 27957792
Am J Clin Nutr. 2005 Feb;81(2):341-54
pubmed: 15699220
Aliment Pharmacol Ther. 2012 May;35(10):1135-44
pubmed: 22469071
Med Hypotheses. 2016 Aug;93:87-92
pubmed: 27372863
Nat Rev Gastroenterol Hepatol. 2010 May;7(5):251-64
pubmed: 20368739
J Gastroenterol Hepatol. 2013 Dec;28 Suppl 4:64-70
pubmed: 24251707
Hepatology. 2016 Jun;63(6):2032-43
pubmed: 26663351
Cell Metab. 2011 Dec 7;14(6):804-10
pubmed: 22152305
Stroke. 2007 Jul;38(7):2142-9
pubmed: 17525399