Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus.


Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
24 Jan 2020
Historique:
received: 25 10 2019
revised: 12 01 2020
accepted: 22 01 2020
entrez: 30 1 2020
pubmed: 30 1 2020
medline: 20 3 2020
Statut: epublish

Résumé

Zika virus (ZIKV) is a mosquito-borne flavivirus associated with a febrile illness as well as severe complications, including microcephaly and Guillain-Barré Syndrome. Antibody cross-reactivity between flaviviruses has been documented, and in regions where ZIKV is circulating, dengue virus (DENV) is also endemic, leaving the potential that previous exposure to DENV could alter clinical features of ZIKV infection. To investigate this, we performed a retrospective case-control study in which we compared Canadian travellers who had been infected with ZIKV and had serological findings indicating previous DENV or other flavivirus exposure (

Identifiants

pubmed: 31991674
pii: v12020140
doi: 10.3390/v12020140
pmc: PMC7077307
pii:
doi:

Substances chimiques

Antibodies, Viral 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Robert A Kozak (RA)

Division of Microbiology, Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.

Lee W Goneau (LW)

Public Health Ontario, Toronto, ON M5G 1V2, Canada.

Cedric DeLima (C)

Public Health Ontario, Toronto, ON M5G 1V2, Canada.

Olivia Varsaneux (O)

Government of Canada, Ottawa, ON K1Z 8R9, Canada.

AliReza Eshaghi (A)

Public Health Ontario, Toronto, ON M5G 1V2, Canada.

Erik Kristjanson (E)

Public Health Ontario, Toronto, ON M5G 1V2, Canada.

Romy Olsha (R)

Public Health Ontario, Toronto, ON M5G 1V2, Canada.

David Safronetz (D)

Special Pathogens Program, National Microbiology Laboratory, Winnipeg, MB R3E 3R2, Canada.

Stephen Perusini (S)

Public Health Ontario, Toronto, ON M5G 1V2, Canada.

Christine Frantz (C)

Public Health Ontario, Toronto, ON M5G 1V2, Canada.

Jonathan B Gubbay (JB)

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Public Health Ontario, Toronto, ON M5G 1V2, Canada.
Hospital for Sick Children, Toronto, ON M5G 1V2, Canada.

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