Antisense oligonucleotides targeting
Animals
Basic Helix-Loop-Helix Transcription Factors
/ genetics
Bone and Bones
/ diagnostic imaging
Cell Cycle Proteins
/ genetics
Disease Models, Animal
Female
Hajdu-Cheney Syndrome
/ metabolism
Macrophages
/ cytology
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Muscle, Skeletal
/ metabolism
Oligonucleotides, Antisense
/ administration & dosage
Osteoclasts
/ cytology
Osteogenesis
Phenotype
Point Mutation
RANK Ligand
/ genetics
Receptor, Notch2
/ antagonists & inhibitors
Hajdu-Cheney syndrome
Notch receptor
antisense oligonucleotides
bone
bone resorption
cell fate
cell signaling
osteoclast
osteoclastogenesis
osteoporosis
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
20 03 2020
20 03 2020
Historique:
received:
11
10
2019
revised:
24
01
2020
pubmed:
30
1
2020
medline:
15
12
2020
entrez:
30
1
2020
Statut:
ppublish
Résumé
Notch receptors play critical roles in cell-fate decisions and in the regulation of skeletal development and bone remodeling. Gain-of-function
Identifiants
pubmed: 31992595
pii: S0021-9258(17)48787-4
doi: 10.1074/jbc.RA119.011440
pmc: PMC7086019
doi:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
Cell Cycle Proteins
0
Hey1 protein, mouse
0
Heyl protein, mouse
0
Notch2 protein, mouse
0
Oligonucleotides, Antisense
0
RANK Ligand
0
Receptor, Notch2
0
Tnfsf11 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3952-3964Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK045227
Pays : United States
Organisme : NIAMS NIH HHS
ID : R61 AR076747
Pays : United States
Informations de copyright
© 2020 Canalis et al.
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