ACC Glu/GABA ratio is decreased in euthymic bipolar disorder I patients: possible in vivo neurometabolite explanation for mood stabilization.
Adolescent
Adult
Anticonvulsants
/ pharmacology
Antipsychotic Agents
/ pharmacology
Bipolar Disorder
/ diagnostic imaging
Female
Glutamate Decarboxylase
/ genetics
Glutamic Acid
/ metabolism
Gyrus Cinguli
/ diagnostic imaging
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Proton Magnetic Resonance Spectroscopy
Young Adult
gamma-Aminobutyric Acid
/ metabolism
Anticonvulsants
Bipolar
GABA
GAD1
Glutamate
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
23
04
2019
accepted:
13
01
2020
pubmed:
30
1
2020
medline:
9
11
2021
entrez:
30
1
2020
Statut:
ppublish
Résumé
Bipolar disorder (BD) is characterized by unstable mood states ranging from mania to depression. Although there is some evidence that mood instability may result from an imbalance between excitatory glutamatergic and inhibitory GABA-ergic neurotransmission, few proton magnetic resonance spectroscopy (
Identifiants
pubmed: 31993746
doi: 10.1007/s00406-020-01096-0
pii: 10.1007/s00406-020-01096-0
doi:
Substances chimiques
Anticonvulsants
0
Antipsychotic Agents
0
Glutamic Acid
3KX376GY7L
gamma-Aminobutyric Acid
56-12-2
Glutamate Decarboxylase
EC 4.1.1.15
glutamate decarboxylase 1
EC 4.1.1.15
Banques de données
ClinicalTrials.gov
['NCT01237158']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
537-547Subventions
Organisme : Sao Paulo Research Foundation (FAPESP)
ID : 2012/23796-2 and 2010/12286-8
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