Complete assignment of Ala, Ile, Leu
4D HMQC-NOESY-HMQC
Human norovirus
MILVA labelling
NMR assignment
Protruding domain
Site-specific isotope labelling
Journal
Biomolecular NMR assignments
ISSN: 1874-270X
Titre abrégé: Biomol NMR Assign
Pays: Netherlands
ID NLM: 101472371
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
21
11
2019
accepted:
16
01
2020
pubmed:
30
1
2020
medline:
18
12
2020
entrez:
30
1
2020
Statut:
ppublish
Résumé
Attachment of human noroviruses to histo blood group antigens (HBGAs) is thought to be essential for infection, although how this binding event promotes infection is unknown. Recent studies have shown that 60% of all GII.4 epidemic strains may undergo a spontaneous post-translational modification (PTM) in an amino acid located adjacent to the binding pocket for HBGAs. This transformation proceeds with an estimated half-life of 1-2 days under physiological conditions, dramatically affecting HBGA recognition. The surface-exposed position of this PTM and its sequence conservation suggests a relevant role in immune escape and host-cell recognition. As a first step towards the understanding of the biological implications of this PTM at atomic resolution, we report the complete assignment of methyl resonances of a MIL
Identifiants
pubmed: 31993958
doi: 10.1007/s12104-020-09932-z
pii: 10.1007/s12104-020-09932-z
pmc: PMC7069894
doi:
Substances chimiques
Amino Acids
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
123-130Références
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