Hippocampal vascular reserve associated with cognitive performance and hippocampal volume.
Aged
Cerebral Arteries
/ pathology
Cerebral Small Vessel Diseases
/ complications
Cognition
/ physiology
Cognitive Dysfunction
/ complications
Female
Gray Matter
/ blood supply
Hippocampus
/ blood supply
Humans
Magnetic Resonance Imaging
/ methods
Male
Memory
/ physiology
Middle Aged
Temporal Lobe
/ blood supply
7 tesla MRI
anterior choroidal artery
cerebral small vessel disease (CSVD)
hippocampus
vascular patterns
Journal
Brain : a journal of neurology
ISSN: 1460-2156
Titre abrégé: Brain
Pays: England
ID NLM: 0372537
Informations de publication
Date de publication:
01 02 2020
01 02 2020
Historique:
received:
17
06
2019
revised:
12
09
2019
accepted:
07
10
2019
pubmed:
30
1
2020
medline:
7
7
2020
entrez:
30
1
2020
Statut:
ppublish
Résumé
Medial temporal lobe dependent cognitive functions are highly vulnerable to hypoxia in the hippocampal region, yet little is known about the relationship between the richness of hippocampal vascular supply and cognition. Hippocampal vascularization patterns have been categorized into a mixed supply from both the posterior cerebral artery and the anterior choroidal artery or a single supply by the posterior cerebral artery only. Hippocampal arteries are small and affected by pathological changes when cerebral small vessel disease is present. We hypothesized, that hippocampal vascularization patterns may be important trait markers for vascular reserve and modulate (i) cognitive performance; (ii) structural hippocampal integrity; and (iii) the effect of cerebral small vessel disease on cognition. Using high-resolution 7 T time-of-flight angiography we manually classified hippocampal vascularization patterns in older adults with and without cerebral small vessel disease in vivo. The presence of a mixed supplied hippocampus was an advantage in several cognitive domains, including verbal list learning and global cognition. A mixed supplied hippocampus also was an advantage for verbal memory performance in cerebral small vessel disease. Voxel-based morphometry showed higher anterior hippocampal grey matter volume in mixed, compared to single supply. We discuss that a mixed hippocampal supply, as opposed to a single one, may increase the reliability of hippocampal blood supply and thereby provide a hippocampal vascular reserve that protects against cognitive impairment.
Identifiants
pubmed: 31994699
pii: 5717233
doi: 10.1093/brain/awz383
pmc: PMC7009470
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
622-634Commentaires et corrections
Type : CommentIn
Type : ErratumIn
Type : CommentIn
Type : CommentIn
Informations de copyright
© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.
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