Anatomical evidence of an indirect pathway for word repetition.
Aged
Aphasia, Primary Progressive
/ diagnostic imaging
Broca Area
/ diagnostic imaging
Case-Control Studies
Cerebral Cortex
/ diagnostic imaging
Diffusion Tensor Imaging
Female
Gray Matter
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neural Pathways
/ diagnostic imaging
Organ Size
Parietal Lobe
/ diagnostic imaging
Wernicke Area
/ diagnostic imaging
White Matter
/ diagnostic imaging
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
11 02 2020
11 02 2020
Historique:
received:
28
11
2018
accepted:
11
08
2019
pubmed:
31
1
2020
medline:
19
5
2020
entrez:
31
1
2020
Statut:
ppublish
Résumé
To combine MRI-based cortical morphometry and diffusion white matter tractography to describe the anatomical correlates of repetition deficits in patients with primary progressive aphasia (PPA). The traditional anatomical model of language identifies a network for word repetition that includes Wernicke and Broca regions directly connected via the arcuate fasciculus. Recent tractography findings of an indirect pathway between Wernicke and Broca regions suggest a critical role of the inferior parietal lobe for repetition. To test whether repetition deficits are associated with damage to the direct or indirect pathway between both regions, tractography analysis was performed in 30 patients with PPA (64.27 ± 8.51 years) and 22 healthy controls. Cortical volume measurements were also extracted from 8 perisylvian language areas connected by the direct and indirect pathways. Compared to healthy controls, patients with PPA presented with reduced performance in repetition tasks and increased damage to most of the perisylvian cortical regions and their connections through the indirect pathway. Repetition deficits were prominent in patients with cortical atrophy of the temporo-parietal region with volumetric reductions of the indirect pathway. The results suggest that in PPA, deficits in repetition are due to damage to the temporo-parietal cortex and its connections to Wernicke and Broca regions. We therefore propose a revised language model that also includes an indirect pathway for repetition, which has important clinical implications for the functional mapping and treatment of neurologic patients.
Identifiants
pubmed: 31996450
pii: WNL.0000000000008746
doi: 10.1212/WNL.0000000000008746
pmc: PMC7136066
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e594-e606Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC008552
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS075075
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P30 AG013854
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056258
Pays : United States
Informations de copyright
Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
Références
Alzheimers Dement. 2019 Apr;15(4):543-552
pubmed: 30765195
Curr Alzheimer Res. 2009 Aug;6(4):331-6
pubmed: 19689231
Neuropsychologia. 2018 Jul 1;115:88-100
pubmed: 29605593
Brain. 2009 Sep;132(Pt 9):2309-16
pubmed: 19690094
J Neurosurg. 2006 May;104(5):845-8
pubmed: 16703895
PLoS One. 2014 Jul 18;9(7):e102557
pubmed: 25036386
Phys Life Rev. 2009 Sep;6(3):121-43
pubmed: 20161054
Brain. 1980 Jun;103(2):337-50
pubmed: 7397481
Brain. 2008 Aug;131(Pt 8):2013-27
pubmed: 18669510
Brain. 2012 May;135(Pt 5):1537-53
pubmed: 22525158
Front Hum Neurosci. 2014 Jan 31;8:24
pubmed: 24550807
Cortex. 2012 Feb;48(2):133-43
pubmed: 21802076
Brain Lang. 2003 Apr;85(1):93-108
pubmed: 12681350
J Cogn Neurosci. 2003 Jul 1;15(5):673-82
pubmed: 12965041
Brain. 1984 Jun;107 ( Pt 2):463-85
pubmed: 6722512
Brain Lang. 2011 Dec;119(3):119-28
pubmed: 21256582
Arch Neurol. 1988 Mar;45(3):275-9
pubmed: 3257689
Neuropsychologia. 1997 Jun;35(6):795-812
pubmed: 9204486
Brain Lang. 1977 Oct;4(4):479-91
pubmed: 922463
Front Hum Neurosci. 2014 May 06;8:246
pubmed: 24834043
Brain. 2010 Jan;133(Pt 1):286-99
pubmed: 19759202
Neurology. 2019 Jan 15;92(3):e224-e233
pubmed: 30578374
Nat Rev Neurosci. 2003 Oct;4(10):829-39
pubmed: 14523382
Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13168-73
pubmed: 23884655
Neuroimage. 2011 Sep 15;58(2):362-80
pubmed: 21718787
Surg Neurol. 2008 Jan;69(1):77-80; discussion 80
pubmed: 17825377
J Neurosci. 2011 Mar 2;31(9):3344-50
pubmed: 21368046
J Neurosci. 2010 May 5;30(18):6334-41
pubmed: 20445059
J Neurosci. 2010 Aug 18;30(33):11057-61
pubmed: 20720112
Brain. 2014 Jul;137(Pt 7):2027-39
pubmed: 24951631
Brain. 2013 Aug;136(Pt 8):2619-28
pubmed: 23820597
Ann Neurol. 2003 Feb;53(2):242-7
pubmed: 12557292
Neurology. 2011 Mar 15;76(11):1006-14
pubmed: 21325651
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5
pubmed: 10984517
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17163-8
pubmed: 17939998
Trends Cogn Sci. 2006 Nov;10(11):480-6
pubmed: 16997610
Neurology. 2016 Apr 12;86(15):1393-1399
pubmed: 26992858
Neuroimage. 2012 Aug 15;62(2):816-47
pubmed: 22584224
Nat Rev Neurol. 2014 Oct;10(10):554-69
pubmed: 25179257
Neurology. 2007 Jul 17;69(3):321; author reply 321-2
pubmed: 17636077
Ann Neurol. 2005 Jan;57(1):8-16
pubmed: 15597383
J Anat. 2000 Oct;197 Pt 3:335-59
pubmed: 11117622
Neuron. 2011 Oct 20;72(2):397-403
pubmed: 22017996
Neuropsychologia. 2015 May;71:18-27
pubmed: 25777496
Ann Neurol. 1982 Jun;11(6):592-8
pubmed: 7114808
Neurology. 2014 Sep 23;83(13):1184-91
pubmed: 25165386
Neuroimage. 2004 May;22(1):42-56
pubmed: 15109996
Aphasiology. 2012;26(3-4):338-354
pubmed: 24976669