Sex Hormone Profile in Pubertal Boys With Gynecomastia and Pseudogynecomastia.
Adolescent
Biomarkers
/ metabolism
Case-Control Studies
Diagnosis, Differential
Follow-Up Studies
Gonadal Steroid Hormones
/ metabolism
Gonadotropins
/ metabolism
Gynecomastia
/ classification
Humans
Insulin-Like Growth Factor Binding Protein 3
/ metabolism
Insulin-Like Growth Factor I
/ metabolism
Male
Prognosis
Prolactin
/ metabolism
Puberty
IGF-1
IGFBP-3
androgens
dihydrotestosterone
estradiol
estrogens
gynecomastia
prolactin
pseudogynecomastia
testosterone
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
06
12
2019
accepted:
27
01
2020
pubmed:
31
1
2020
medline:
5
1
2021
entrez:
31
1
2020
Statut:
ppublish
Résumé
Gynecomastia (defined by proliferation of glandular elements) and pseudogynecomastia (defined by adipose tissue) are frequent in pubertal boys. An association with sex hormones and the growth hormone axis has been discussed. The objective of this work is to compare sex hormones, insulin-like growth factor 1 (IGF-1), and insulin-like growth factor binding protein 3 (IGFBP-3) between boys with gynecomastia and pseudogynecomastia (separation by ultrasound). An observational study was performed. The setting of this study was an outpatient clinic. A total of 124 pubertal boys (mean age 14 ± 2 years) with breast enlargement and 84 healthy boys (mean age 14 ± 2 years) without breast enlargement participated in this study. No interventions were performed. Measurements were taken for sex hormones (progesterone, estradiol [E2], estriol, estrone, androstendione, testosterone [T], dihydrotestosterone) measured by liquid chromatography-tandem mass spectrometry, as well as gonadotropins, prolactin, IGF-1, and IGFBP-3. Eighty-six boys suffered from gynecomastia and 38 from pseudogynecomastia. In boys with gynecomastia, the E2/T ratio (median 22, interquartile range [IQR] 8-75) was significantly (P < .05) higher compared to boys with pseudogynecomastia (median 12, IQR 5-21) or healthy controls without breast enlargement (median 18, IQR 6-44) even after adjustment for testes volume. T concentrations were significantly (P < .05) lower in boys with gynecomastia (median 1.8, IQR 0.7-4.2 nM/L) compared to boys with pseudogynecomastia (median 4.3, IQR 1.4-6.9 nM/L) or healthy controls without breast enlargement (median 3.1, IQR 0.6-7.6 nM/L). Boys with gynecomastia did not differ from boys with pseudogynecomastia according to other sex hormones, prolactin, IGF-1, or IGFBP-3 concentrations. True gynecomastia is characterized by a relative T deficiency to E2 concentrations in contrast to pseudogynecomastia.
Identifiants
pubmed: 31996898
pii: 5717688
doi: 10.1210/clinem/dgaa044
pii:
doi:
Substances chimiques
Biomarkers
0
Gonadal Steroid Hormones
0
Gonadotropins
0
IGF1 protein, human
0
IGFBP3 protein, human
0
Insulin-Like Growth Factor Binding Protein 3
0
Insulin-Like Growth Factor I
67763-96-6
Prolactin
9002-62-4
Banques de données
ClinicalTrials.gov
['NCT00435734']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.