New approach in the characterization of bioactive compounds isolated from Calycotome spinosa (L.) Link leaves by the use of negative electrospray ionization LITMS
Anti-Bacterial Agents
/ isolation & purification
Antioxidants
/ pharmacology
Chromatography, Liquid
/ methods
Genista
/ chemistry
Inhibitory Concentration 50
Microbial Sensitivity Tests
Plant Extracts
/ pharmacology
Plant Leaves
/ chemistry
Polyphenols
/ analysis
Spectrum Analysis
/ methods
Staphylococcus aureus
/ drug effects
5-Hydroxy-1H-indole
Biological activities: antioxidant and antimicrobial
Calycotome spinosa (L.) Link
LC-ESI-MS/MS
LITMS(n)
NMR
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
03
08
2019
revised:
13
12
2019
accepted:
20
12
2019
pubmed:
31
1
2020
medline:
12
3
2021
entrez:
31
1
2020
Statut:
ppublish
Résumé
Two novel compounds were isolated for the first time from Calycotome spinosa (L.) Link, an alkaloid 5-Hydroxy-1H-indole (4) and a cyclitol D-pinitol (5), together with the three well-known flavonoids; Chrysin-7-O-(β-D-glucopyranoside) (1), Chrysin-7-O-β-D-(6″-acetyl)glycopyranoside (2) and Apigenin-7-O-β-D-glycopyranoside (3). The chemical structures of the isolated compounds were elucidated by spectroscopic data and mass spectrometric analyses; including a fresh approach 1D-NMR, 2D-NMR with LC-ESI-MS/MS. In this study, the new compound (4) that has been obtained from the leaves MeOH extract presented the best radical scavenging activity (DPPH) (IC
Identifiants
pubmed: 32000017
pii: S0045-2068(19)31215-5
doi: 10.1016/j.bioorg.2019.103535
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antioxidants
0
Plant Extracts
0
Polyphenols
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103535Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.