Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss.

Animals Cells, Cultured Disease Models, Animal Female Gene Regulatory Networks Hair Cells, Auditory / cytology Humans Male Mice NADPH Oxidases / genetics Oxidation-Reduction Presbycusis / genetics Reactive Oxygen Species / metabolism Up-Regulation
Age-related hearing loss Auditory neurons Excitotoxicity Glutamatergic signaling NADPH oxidase Presbycusis

Journal

Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639

Informations de publication

Date de publication:
02 2020
Historique:
received: 22 11 2019
revised: 08 01 2020
accepted: 14 01 2020
pubmed: 31 1 2020
medline: 17 4 2021
entrez: 31 1 2020
Statut: ppublish

Résumé

Age-related hearing (ARHL) loss affects a large part of the human population with a major impact on our aging societies. Yet, underlying mechanisms are not understood, and no validated therapy or prevention exists. NADPH oxidases (NOX), are important sources of reactive oxygen species (ROS) in the cochlea and might therefore be involved in the pathogenesis of ARHL. Here we investigate ARHL in a mouse model. Wild type mice showed early loss of hearing and cochlear integrity, while animals deficient in the NOX subunit p22

Identifiants

DOI: 10.1016/j.redox.2020.101434 PMID: 32000019 PMC: PMC7016250
pubmed: 32000019
pii: S2213-2317(19)31455-7
doi: 10.1016/j.redox.2020.101434
pmc: PMC7016250
pii:
doi:

Substances chimiques

Reactive Oxygen Species 0
NADPH Oxidases EC 1.6.3.-
CYBA protein, human EC 1.6.3.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101434

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors have declared that no conflict of interest exists.

Références

Antioxid Redox Signal. 2014 Aug 20;21(6):859-62
pubmed: 24930772
Antioxid Redox Signal. 2010 Sep 1;13(5):589-98
pubmed: 20214492
Biochem Biophys Res Commun. 2017 Apr 1;485(2):388-394
pubmed: 28216161
J Cell Sci. 2003 Jul 1;116(Pt 13):2665-75
pubmed: 12746490
PLoS Genet. 2015 Apr 16;11(4):e1005094
pubmed: 25880434
Methods Mol Biol. 2019;1982:17-36
pubmed: 31172464
Biochem Biophys Res Commun. 2011 Nov 11;415(1):94-8
pubmed: 22020098
Methods Mol Biol. 2009;493:141-62
pubmed: 18839346
Nat Rev Neurol. 2015 Mar;11(3):166-75
pubmed: 25686757
J Biol Chem. 2004 Oct 29;279(44):45935-41
pubmed: 15322091
Cell Calcium. 2008 Apr;43(4):356-66
pubmed: 17719086
Antioxid Redox Signal. 2018 Oct 20;29(12):1125-1146
pubmed: 29357673
Mol Neurobiol. 2015 Feb;51(1):252-67
pubmed: 24781382
Neuroscience. 2019 May 21;407:8-20
pubmed: 30099118
Nat Commun. 2015 May 12;6:7115
pubmed: 25965946
J Clin Invest. 2008 Mar;118(3):1176-85
pubmed: 18292807
Free Radic Biol Med. 2012 Feb 15;52(4):725-34
pubmed: 22182486
Hear Res. 2010 Sep 1;268(1-2):85-92
pubmed: 20470874
Redox Biol. 2018 Oct;19:301-317
pubmed: 30199819
Methods Mol Biol. 2019;1982:191-229
pubmed: 31172474
Lancet. 2005 Sep 24-30;366(9491):1111-20
pubmed: 16182900
Front Cell Neurosci. 2018 Oct 17;12:364
pubmed: 30386210
Oxid Med Cell Longev. 2014;2014:582849
pubmed: 25110550
Genes Dev. 2004 Mar 1;18(5):486-91
pubmed: 15014044
Swiss Med Wkly. 2012 Aug 17;142:w13659
pubmed: 22903797
Am J Psychiatry. 2018 Mar 1;175(3):215-224
pubmed: 29202654
Curr Pharm Des. 2015;21(41):5977-87
pubmed: 26510434
Front Aging Neurosci. 2015 Apr 21;7:58
pubmed: 25954196
Hear Res. 2017 Mar;345:43-51
pubmed: 28034618
J Neurochem. 2018 Aug;146(4):459-473
pubmed: 29675997
Eur Arch Otorhinolaryngol. 2017 Apr;274(4):1821-1834
pubmed: 27858145
Eur J Neurosci. 2005 Sep;22(5):1109-19
pubmed: 16176352
Front Cell Neurosci. 2015 Jul 27;9:276
pubmed: 26283913
Nat Chem Biol. 2015 Jan;11(1):64-70
pubmed: 25402766
Cell Stem Cell. 2011 Jan 7;8(1):59-71
pubmed: 21211782
Sci Rep. 2017 Dec;7(1):66
pubmed: 28242877
Pharmacogenomics J. 2012 Feb;12(1):30-44
pubmed: 20644563
Hear Res. 2015 Jul;325:42-8
pubmed: 25818515
Redox Biol. 2016 Oct;9:287-295
pubmed: 27614387
J Biol Chem. 2004 Oct 29;279(44):46065-72
pubmed: 15326186
J Assoc Res Otolaryngol. 2010 Dec;11(4):725-32
pubmed: 20821033
Mol Ther Nucleic Acids. 2019 Mar 1;14:351-363
pubmed: 30665184
J Neurosci. 2016 Apr 6;36(14):3962-77
pubmed: 27053204
Neurochem Int. 2015 Aug;87:106-9
pubmed: 26065937
Front Biosci (Landmark Ed). 2011 Jan 01;16:553-67
pubmed: 21196188
J Clin Invest. 2018 Nov 1;128(11):4938-4955
pubmed: 30247156
Purinergic Signal. 2005 Jun;1(2):111-34
pubmed: 18404497
J Neurosci. 2017 Mar 15;37(11):2960-2975
pubmed: 28193694
Redox Biol. 2017 Oct;13:82-93
pubmed: 28575744
J Neurosci. 2017 Jun 21;37(25):6162-6175
pubmed: 28539424
Cell Rep. 2018 Dec 18;25(12):3451-3464.e3
pubmed: 30566869
FEBS J. 2013 May;280(9):1944-65
pubmed: 23461806
Neurosci Lett. 2012 Jun 14;518(1):60-3
pubmed: 22580201
Neural Plast. 2018 Jul 31;2018:1970150
pubmed: 30154835

Auteurs

Francis Rousset (F)

Hearing and Olfaction Research Laboratory, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland. Electronic address: Francis.Rousset@unige.ch.

German Nacher-Soler (G)

Hearing and Olfaction Research Laboratory, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.

Marta Coelho (M)

Hearing and Olfaction Research Laboratory, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.

Sten Ilmjarv (S)

Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.

Vivianne Beatrix Christina Kokje (VBC)

Hearing and Olfaction Research Laboratory, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.

Antoine Marteyn (A)

Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.

Yves Cambet (Y)

Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland; READS Unit, Faculty of Medicine, University of Geneva, Switzerland.

Michael Perny (M)

Department of Biomedical Research (DBMR), University of Bern, Switzerland; Department of Otorhinolaryngology, Inselspital Bern, Switzerland.

Marta Roccio (M)

Department of Biomedical Research (DBMR), University of Bern, Switzerland; Department of Otorhinolaryngology, Inselspital Bern, Switzerland.

Vincent Jaquet (V)

Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland; READS Unit, Faculty of Medicine, University of Geneva, Switzerland.

Pascal Senn (P)

Hearing and Olfaction Research Laboratory, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland; Department of Clinical Neurosciences, Service of ORL & Head and Neck Surgery, University Hospital of Geneva, Switzerland.

Karl Heinz Krause (KH)

Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Redox activation of excitatory pathways in...
questionsmedicales.fr › Cellules › Cellules cultivées › Redox activation of excitatory pathways in...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Redox activation of excitatory pathways in...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Réseaux de régulation génique › Redox activation of excitatory pathways in...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Mécanorécepteurs › Cellules neuroépithéliales › Cellules ciliées auditives › Redox activation of excitatory pathways in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Redox activation of excitatory pathways in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Redox activation of excitatory pathways in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › NADPH oxidase › Redox activation of excitatory pathways in...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Redox activation of excitatory pathways in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles de l'audition › Perte d'audition › Surdité neurosensorielle › Presbyacousie › Redox activation of excitatory pathways in...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Redox activation of excitatory pathways in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › Redox activation of excitatory pathways in...