White matter structure and myelin-related gene expression alterations with experience in adult rats.

Animals Brain Diffusion Tensor Imaging Gene Expression Male Myelin Sheath Neuronal Plasticity / physiology Perception / physiology Rats Rats, Long-Evans White Matter
Genome-wide RNA sequencing MRI Myelin Plasticity White matter mRNA expression

Journal

Progress in neurobiology
ISSN: 1873-5118
Titre abrégé: Prog Neurobiol
Pays: England
ID NLM: 0370121

Informations de publication

Date de publication:
04 2020
Historique:
received: 29 06 2019
revised: 19 12 2019
accepted: 24 01 2020
pubmed: 1 2 2020
medline: 9 2 2021
entrez: 1 2 2020
Statut: ppublish

Résumé

White matter (WM) plasticity during adulthood is a recently described phenomenon by which experience can shape brain structure. It has been observed in humans using diffusion tensor imaging (DTI) and myelination has been suggested as a possible mechanism. Here, we set out to identify molecular and cellular changes associated with WM plasticity measured by DTI. We combined DTI, immunohistochemistry and mRNA expression analysis and examined the effects of somatosensory experience in adult rats. First, we observed experience-induced DTI differences in WM and in grey matter structure. C-Fos mRNA expression, a marker of cortical activity, in the barrel cortex correlated with the MRI WM metrics, indicating that molecular correlates of cortical activity relate to macroscale measures of WM structure. Analysis of myelin-related genes revealed higher myelin basic protein (MBP) mRNA expression. Higher MBP protein expression was also found via immunohistochemistry in WM. Finally, unbiased RNA sequencing analysis identified 134 differentially expressed genes encoding proteins involved in functions related to cell proliferation and differentiation, regulation of myelination and neuronal activity modulation. In conclusion, macroscale measures of WM plasticity are supported by both molecular and cellular evidence and confirm that myelination is one of the underlying mechanisms.

Identifiants

DOI: 10.1016/j.pneurobio.2020.101770 PMID: 32001310 PMC: PMC7086231
pubmed: 32001310
pii: S0301-0082(20)30025-3
doi: 10.1016/j.pneurobio.2020.101770
pmc: PMC7086231
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101770

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT090955AIA
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT110027/Z/15/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203139/Z/16/Z
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C5255/A15935
Pays : United Kingdom

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest We report no conflict of interest.

Références

Neuroscience. 2015 Jan 22;284:962-71
pubmed: 25451297
Neuroimage. 2014 May 15;92:381-97
pubmed: 24530839
Neuron. 2002 Apr 11;34(2):265-73
pubmed: 11970868
J Neurosci. 2015 May 20;35(20):7850-65
pubmed: 25995471
Nature. 2006 Jun 22;441(7096):979-83
pubmed: 16791195
Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):11832-11837
pubmed: 30373833
Magn Reson Med. 2003 Oct;50(4):743-8
pubmed: 14523960
Science. 2014 Oct 17;346(6207):318-22
pubmed: 25324381
Synapse. 2008 Apr;62(4):302-9
pubmed: 18241047
Nat Neurosci. 2016 Sep;19(9):1210-1217
pubmed: 27455109
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
J Neurosci. 2013 Dec 11;33(50):19499-503
pubmed: 24336716
EMBO Mol Med. 2016 Dec 1;8(12):1409-1420
pubmed: 27861125
Front Neurosci. 2016 Oct 13;10:460
pubmed: 27790087
Nat Rev Mol Cell Biol. 2001 Aug;2(8):599-609
pubmed: 11483993
Prog Neurobiol. 1996 Oct;50(2-3):83-107
pubmed: 8971979
Nat Neurosci. 2015 May;18(5):628-30
pubmed: 25849985
Cell Cycle. 2009 Apr 15;8(8):1168-75
pubmed: 19282669
J Neurosci. 2010 Sep 1;30(35):11670-7
pubmed: 20810887
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9887-92
pubmed: 8790426
J Neurosci. 2012 Jun 27;32(26):8855-64
pubmed: 22745486
Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4643-8
pubmed: 15070771
Oncogene. 2007 May 14;26(22):3291-310
pubmed: 17496923
PLoS One. 2009;4(3):e4936
pubmed: 19295912
Elife. 2017 Jan 28;6:
pubmed: 28130923
Neuron. 2017 Dec 20;96(6):1239-1251
pubmed: 29268094
Nat Neurosci. 2012 Mar 18;15(4):528-36
pubmed: 22426254
Genome Biol. 2003;4(5):P3
pubmed: 12734009
Nat Neurosci. 2018 May;21(5):696-706
pubmed: 29556025
Nat Commun. 2018 Jan 22;9(1):306
pubmed: 29358753
Trends Neurosci. 2010 May;33(5):230-40
pubmed: 20223527
Science. 2014 May 2;344(6183):1252304
pubmed: 24727982
Cell. 2014 Jan 16;156(1-2):277-90
pubmed: 24439382
Neuron. 2012 Mar 22;73(6):1195-203
pubmed: 22445346
PLoS Biol. 2007 Nov;5(11):e305
pubmed: 18001152
Neuroimage. 2006 Jul 15;31(4):1487-505
pubmed: 16624579
Glia. 2012 Mar;60(3):476-86
pubmed: 22144101
J Neurosci. 2016 Aug 31;36(35):9186-200
pubmed: 27581459
J Neurosci. 2014 Apr 23;34(17):6078-83
pubmed: 24760867
Oncogene. 2005 Nov 14;24(50):7455-64
pubmed: 16288292
Neuroimage. 2007 Apr 1;35(2):553-65
pubmed: 17292630
J Neurochem. 2007 Mar;100(6):1480-93
pubmed: 17348861
J Neurosci. 1996 Jul 15;16(14):4411-9
pubmed: 8699252
Biochem Soc Trans. 2013 Aug;41(4):944-50
pubmed: 23863161
Neuroimage. 2004;23 Suppl 1:S208-19
pubmed: 15501092
J Neurosci. 2013 Jul 31;33(31):12844-50
pubmed: 23904619
Nucleic Acids Res. 2009 Jan;37(1):1-13
pubmed: 19033363
Cell Res. 2002 Mar;12(1):9-18
pubmed: 11942415
Cell Mol Life Sci. 2012 Sep;69(17):2879-94
pubmed: 22441408
J Neurosci. 2016 Jun 29;36(26):6937-48
pubmed: 27358452
Curr Med Res Opin. 2011 Jul;27(7):1415-23
pubmed: 21595605
NMR Biomed. 2003 Apr;16(2):77-81
pubmed: 12730948
Neuron. 2012 Mar 22;73(6):1058-60
pubmed: 22445333
J Neurosci. 2017 Aug 23;37(34):8239-8255
pubmed: 28760859
Nature. 2002 Dec 19-26;420(6917):788-94
pubmed: 12490942
Cell Mol Neurobiol. 2002 Apr;22(2):191-5
pubmed: 12363201
Nat Neurosci. 2009 Nov;12(11):1370-1
pubmed: 19820707
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6339-E6346
pubmed: 29915074
Neuron. 2002 Aug 15;35(4):605-23
pubmed: 12194863
Glia. 2014 Dec;62(12):2096-109
pubmed: 25060812
PLoS One. 2011;6(6):e20678
pubmed: 21701690
J Neurochem. 2009 Jun;109(5):1440-51
pubmed: 19453943
Hum Brain Mapp. 2016 Apr;37(4):1486-511
pubmed: 26848101
Prog Neurobiol. 2013 Apr;103:3-27
pubmed: 23195880

Auteurs

Cassandra Sampaio-Baptista (C)

Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK. Electronic address: Cassandra.sampaiobaptista@ndcn.ox.ac.uk.

Astrid Vallès (A)

Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Nijmegen, 6525 GA Nijmegen, The Netherlands; Department of Neurocognition, Faculty of Psychology and Neurosciences, Maastricht University, 6200 MD Maastricht, The Netherlands.

Alexandre A Khrapitchev (AA)

Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.

Guus Akkermans (G)

Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Nijmegen, 6525 GA Nijmegen, The Netherlands.

Anderson M Winkler (AM)

Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

Sean Foxley (S)

Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

Nicola R Sibson (NR)

Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.

Mark Roberts (M)

Department of Neurocognition, Faculty of Psychology and Neurosciences, Maastricht University, 6200 MD Maastricht, The Netherlands.

Karla Miller (K)

Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

Mathew E Diamond (ME)

Tactile Perception and Learning Lab, International School for Advanced Studies (SISSA), 34136 Trieste, Italy.

Gerard J M Martens (GJM)

Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Nijmegen, 6525 GA Nijmegen, The Netherlands.

Peter De Weerd (P)

Department of Neurocognition, Faculty of Psychology and Neurosciences, Maastricht University, 6200 MD Maastricht, The Netherlands; Department of Cognitive Neuroscience, Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, 6500 HB Nijmegen, The Netherlands; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, 6229 ER Maastricht, The Netherlands.

Heidi Johansen-Berg (H)

Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › White matter structure and myelin-related gene...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › White matter structure and myelin-related gene...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Imagerie par tenseur de diffusion › White matter structure and myelin-related gene...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › White matter structure and myelin-related gene...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Gaine de myéline › White matter structure and myelin-related gene...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › White matter structure and myelin-related gene...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › White matter structure and myelin-related gene...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › White matter structure and myelin-related gene...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Long-Evans › White matter structure and myelin-related gene...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › White matter structure and myelin-related gene...