The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs.
BRET experiments
GPCR oligomerisation
beta-arrestin
cell biology
in vitro pharmacology
in vivo pharmacology
knockout animals
mouse
neuroscience
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
31 01 2020
31 01 2020
Historique:
received:
25
07
2019
accepted:
30
01
2020
pubmed:
1
2
2020
medline:
20
4
2021
entrez:
1
2
2020
Statut:
epublish
Résumé
GPR88 is an orphan G protein-coupled receptor (GPCR) considered as a promising therapeutic target for neuropsychiatric disorders; its pharmacology, however, remains scarcely understood. Based on our previous report of increased delta opioid receptor activity in
Identifiants
pubmed: 32003745
doi: 10.7554/eLife.50519
pii: 50519
pmc: PMC7012601
doi:
pii:
Substances chimiques
Gpr88 protein, mouse
0
Receptors, G-Protein-Coupled
0
Receptors, Opioid
0
beta-Arrestins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Region Centre-Val de Loire
ID : ARD2020 Biomedicaments - GPCRAb
Organisme : Fonds Unique Interministériel
ID : ATHOS
Organisme : H2020 Marie Skłodowska-Curie Actions
ID : AgreenSkills Program Postdoctoral Fellowship
Organisme : Marie-Curie/AgreeSkills Program
ID : Postdoctoral Fellowshio
Informations de copyright
© 2020, Laboute et al.
Déclaration de conflit d'intérêts
TL, JG, LP, YC, FR, MG, CG, AL, JD, AP, BK, JL, JB No competing interests declared
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