Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP.

Animals Animals, Newborn CRISPR-Cas Systems / genetics Calcium / metabolism Electrophysiological Phenomena Gene Editing Gene Knockout Techniques Hemodynamics Ischemic Preconditioning, Myocardial Mice, Knockout Mitochondria, Heart / metabolism Myocardial Reperfusion Injury / metabolism Myocardium / metabolism Myocytes, Cardiac / metabolism Organ Specificity Perfusion Phenotype Potassium Channels / metabolism Potassium Channels, Inwardly Rectifying / deficiency
Bartter's syndrome Ischemic preconditioning Kcnj1 or Kir1.1 or ROMK Mitochondrial ATP-sensitive potassium channel Mitochondrial permeability transition pore Renal potassium channel

Journal

Journal of molecular and cellular cardiology
ISSN: 1095-8584
Titre abrégé: J Mol Cell Cardiol
Pays: England
ID NLM: 0262322

Informations de publication

Date de publication:
02 2020
Historique:
received: 01 07 2019
revised: 16 01 2020
accepted: 23 01 2020
pubmed: 1 2 2020
medline: 23 1 2021
entrez: 1 2 2020
Statut: ppublish

Résumé

The renal-outer-medullary‑potassium (ROMK) channel, mutated in Bartter's syndrome, regulates ion exchange in kidney, but its extra-renal functions remain unknown. Additionally, ROMK was postulated to be the pore-forming subunit of the mitochondrial ATP-sensitive K

Identifiants

DOI: 10.1016/j.yjmcc.2020.01.010 PMID: 32004507 PMC: PMC7849919
pubmed: 32004507
pii: S0022-2828(20)30022-5
doi: 10.1016/j.yjmcc.2020.01.010
pmc: PMC7849919
mid: NIHMS1558026
pii:
doi:

Substances chimiques

Kcnj1 protein, mouse 0
Potassium Channels 0
Potassium Channels, Inwardly Rectifying 0
mitochondrial K(ATP) channel 0
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

176-189

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL092141
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137259
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no competing interests.

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Auteurs

Kyriakos N Papanicolaou (KN)

Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Deepthi Ashok (D)

Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Ting Liu (T)

Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Tyler M Bauer (TM)

Cardiovascular Branch, NHLBI, NIH, 10 Center Drive, Bethesda, MD, USA.

Junhui Sun (J)

Cardiovascular Branch, NHLBI, NIH, 10 Center Drive, Bethesda, MD, USA.

Zhen Li (Z)

Cardiovascular Center of Excellence, Louisiana State University (LSU) Health Sciences Center, New Orleans, LA, USA; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, LA, USA.

Eduardo da Costa (E)

Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Charles Crepy D'Orleans (CC)

Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Sara Nathan (S)

Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

David J Lefer (DJ)

Cardiovascular Center of Excellence, Louisiana State University (LSU) Health Sciences Center, New Orleans, LA, USA; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, LA, USA.

Elizabeth Murphy (E)

Cardiovascular Branch, NHLBI, NIH, 10 Center Drive, Bethesda, MD, USA.

Nazareno Paolocci (N)

Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Sciences, University of Padova, Padova, Italy.

D Brian Foster (DB)

Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Brian O'Rourke (B)

Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: bor@jhmi.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Eucaryotes › Animaux › Groupes animaux › Animaux nouveau-nés › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes électrophysiologiques › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Édition de gène › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-out de gènes › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Techniques d'investigation › Préconditionnement ischémique › Préconditionnement ischémique myocardique › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondries du muscle › Mitochondries du myocarde › Global knockout of ROMK potassium channel...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Lésion d'ischémie-reperfusion › Lésion de reperfusion myocardique › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Phénomènes physiologiques › Spécificité d'organe › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Techniques d'investigation › Perfusion › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Global knockout of ROMK potassium channel...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques rectifiants entrants › Global knockout of ROMK potassium channel...