Demarcation of Sepsis-Induced Peripheral and Central Acidosis with pH (Low) Insertion Cycle Peptide.
64Cu
acidosis
neuroinflammation
pHLIC
sepsis
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
08
07
2019
accepted:
22
01
2020
pubmed:
2
2
2020
medline:
6
3
2021
entrez:
2
2
2020
Statut:
ppublish
Résumé
Acidosis is a key driver for many diseases, including cancer, sepsis, and stroke. The spatiotemporal dynamics of dysregulated pH across disease remain elusive, and current diagnostic strategies do not provide localization of pH alterations. We sought to explore if PET imaging using hydrophobic cyclic peptides that partition into the cellular membrane at low extracellular pH (denoted as pH [low] insertion cycles, or pHLIC) can permit accurate in vivo visualization of acidosis.
Identifiants
pubmed: 32005774
pii: jnumed.119.233072
doi: 10.2967/jnumed.119.233072
pmc: PMC7456172
doi:
Substances chimiques
Peptides, Cyclic
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1361-1368Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA232130
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM073857
Pays : United States
Informations de copyright
© 2020 by the Society of Nuclear Medicine and Molecular Imaging.
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