Assessing Protein Function Through Structural Similarities with CATH.

Databases, Protein Protein Structure, Tertiary Proteins / chemistry Sequence Analysis, Protein Sequence Homology, Amino Acid Structural Homology, Protein
Functional assignment Protein function Protein structure Structure classification Structure similarity

Journal

Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969

Informations de publication

Date de publication:
2020
Historique:
entrez: 2 2 2020
pubmed: 2 2 2020
medline: 28 1 2021
Statut: ppublish

Résumé

The functional diversity of proteins is closely related to their differences in sequence and structure. Despite variations in functional sites, global structural similarity is a valuable source of information when assessing potential functional similarities between proteins. The CATH database contains a well-established hierarchical classification of more than 430,000 protein domain structures and nearly 95 million protein domain sequences, with integrated functional annotations for each represented family. The present chapter provides an overview of the main features of CATH with emphasis on exploiting structural similarities to obtain functional information for proteins.

Identifiants

DOI: 10.1007/978-1-0716-0270-6_4 PMID: 32006277
pubmed: 32006277
doi: 10.1007/978-1-0716-0270-6_4
doi:

Substances chimiques

Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

43-57

Subventions

Organisme : Wellcome Trust
ID : 104960/Z/14/Z
Pays : United Kingdom

Auteurs

Natalie L Dawson (NL)

Institute of Structural and Molecular Biology, University College London, London, UK. natalie.dawson.09@ucl.ac.uk.

Christine Orengo (C)

Institute of Structural and Molecular Biology, University College London, London, UK.

Zoltán Gáspári (Z)

Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Mémorisation et recherche des informations › Bases de données comme sujet › Bases de données factuelles › Bases de données génétiques › Bases de données de protéines › Assessing Protein Function Through Structural...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Assessing Protein Function Through Structural...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Assessing Protein Function Through Structural...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence de protéine › Assessing Protein Function Through Structural...
questionsmedicales.fr › Phénomènes génétiques › Similitude de séquences › Similitude de séquences d'acides aminés › Assessing Protein Function Through Structural...
questionsmedicales.fr › Phénomènes génétiques › Similitude structurale de protéines › Assessing Protein Function Through Structural...