Adolescent cannabis exposure increases heroin reinforcement in rats genetically vulnerable to addiction.
Adolescence
Gateway hypothesis
Genetic vulnerability
Heroin
Self-administration
Δ(9)-tetrahydrocannabinol
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
20
09
2019
revised:
12
12
2019
accepted:
20
01
2020
pubmed:
3
2
2020
medline:
7
4
2021
entrez:
3
2
2020
Statut:
ppublish
Résumé
On the basis of epidemiological studies it has been proposed that cannabis use plays a causal role in the abuse of highly addictive drugs (Gateway Hypothesis). However, epidemiological studies are intrinsically unable to provide evidence of causality. Experimental studies can provide this evidence but they are feasible only in animal models and to date such evidence is lacking. In view of the importance of genetic factors in drug abuse, we investigated the influence of adolescent cannabis exposure on adult heroin reinforcement in two inbred rat strains differentially vulnerable to drugs of abuse, addiction prone Lewis (LEW) and addiction resistant Fischer 344 (F344) strains. Male LEW and F344 rats aged six weeks were exposed to increasing Δ
Identifiants
pubmed: 32007624
pii: S0028-3908(20)30040-X
doi: 10.1016/j.neuropharm.2020.107974
pii:
doi:
Substances chimiques
Analgesics, Opioid
0
Heroin
70D95007SX
Dronabinol
7J8897W37S
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107974Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None.