pH dependent degradation properties of lactide based 3D microchamber arrays for sustained cargo release.
Biodegradable
Cargo encapsulation
Microchambers arrays
Polylactic acid
pH stability
Journal
Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Titre abrégé: Colloids Surf B Biointerfaces
Pays: Netherlands
ID NLM: 9315133
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
30
09
2019
revised:
23
01
2020
accepted:
24
01
2020
pubmed:
3
2
2020
medline:
24
11
2020
entrez:
3
2
2020
Statut:
ppublish
Résumé
Encapsulation of small water soluble molecules is important in a large variety of applications, ranging from medical substance releasing implants in the field of medicine over release of catalytically active substances in the field of chemical processing to anti-corrosion agents in industry. In this work polylactic acid (PLA) based hollow-structured microchamber (MC) arrays are fabricated via one-step dip coating of a silicone rubber stamp into PLA solution. These PLA MCs are able to retain small water soluble molecules (Rhodamine B) stably entrapped within aqueous environments. It is shown, that degradation of PLA MCs strongly depends on environmental conditions like surrounding pH and follows first order degradation kinetics. This pH dependent PLA MC degradation can be utilized to control the release kinetics of encapsulated cargo.
Identifiants
pubmed: 32007703
pii: S0927-7765(20)30056-4
doi: 10.1016/j.colsurfb.2020.110826
pii:
doi:
Substances chimiques
Polyesters
0
poly(lactide)
459TN2L5F5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110826Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.