A longitudinal study of cognitive function in multiple sclerosis: is decline inevitable?
CIS
Cognitive impairment
Longitudinal study
Multiple sclerosis
RRMS
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
13
10
2019
accepted:
20
01
2020
revised:
15
01
2020
pubmed:
3
2
2020
medline:
9
2
2021
entrez:
3
2
2020
Statut:
ppublish
Résumé
Numerous cross-sectional studies report cognitive impairment in multiple sclerosis (MS), but longitudinal studies with sufficiently long-term follow-up are scarce. We aimed to investigate the cognitive 10-year course of a cohort of MS patients. 59 patients with clinically isolated syndrome (CIS) or relapsing-remitting (RR) MS were evaluated with Rao's Brief Repeatable Battery of Neuropsychological Tests at baseline and follow-up (at least 10 years later). They constituted 47.2% of 124 consecutive CIS and RRMS patients originally evaluated at baseline. Patients assessed at follow-up were well matched for baseline clinical characteristics with dropouts. The proportion of MS patients with overall cognitive impairment was increased by 10% within the 10-year period. When grouped on the basis of impairment in specific cognitive domains at baseline, patients originally impaired showed improvement at follow-up, while the opposite trend was observed for patients non-impaired at first assessment. A detailed case-by-case investigation revealed mixed evolution patterns, several patients fail in fewer domains at follow-up compared to baseline or failing at different domains at follow-up compared to baseline. This study suggests a more fluid picture for the evolution of cognitive function in a subgroup of MS patients and contradicts the concept of an inevitable, progressively evolving "dementia".
Sections du résumé
BACKGROUND
BACKGROUND
Numerous cross-sectional studies report cognitive impairment in multiple sclerosis (MS), but longitudinal studies with sufficiently long-term follow-up are scarce.
OBJECTIVE
OBJECTIVE
We aimed to investigate the cognitive 10-year course of a cohort of MS patients.
METHODS
METHODS
59 patients with clinically isolated syndrome (CIS) or relapsing-remitting (RR) MS were evaluated with Rao's Brief Repeatable Battery of Neuropsychological Tests at baseline and follow-up (at least 10 years later). They constituted 47.2% of 124 consecutive CIS and RRMS patients originally evaluated at baseline. Patients assessed at follow-up were well matched for baseline clinical characteristics with dropouts.
RESULTS
RESULTS
The proportion of MS patients with overall cognitive impairment was increased by 10% within the 10-year period. When grouped on the basis of impairment in specific cognitive domains at baseline, patients originally impaired showed improvement at follow-up, while the opposite trend was observed for patients non-impaired at first assessment. A detailed case-by-case investigation revealed mixed evolution patterns, several patients fail in fewer domains at follow-up compared to baseline or failing at different domains at follow-up compared to baseline.
CONCLUSIONS
CONCLUSIONS
This study suggests a more fluid picture for the evolution of cognitive function in a subgroup of MS patients and contradicts the concept of an inevitable, progressively evolving "dementia".
Identifiants
pubmed: 32008073
doi: 10.1007/s00415-020-09720-8
pii: 10.1007/s00415-020-09720-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1464-1475Subventions
Organisme : State Scholarships Foundation
ID : MIS-5000432
Références
Bergendal G, Fredrikson S, Almkvist O (2007) Selective decline in information processing in subgroups of multiple sclerosis: an 8 year old longitudinal study. Eur Neurol 57:193–202
pubmed: 17272938
doi: 10.1159/000099158
DeLuca J, Chelune GJ, Tulsky DS et al (2004) Is speed of processing or working memory the primary information processing deficit in multiple sclerosis? J Clin Exp Neuropsychol 26:550–562
pubmed: 15512942
doi: 10.1080/13803390490496641
Janculjak D, Mubrin A, Brinar V et al (2002) Changes of attention and memory in a group of patients with multiple sclerosis. Clin Neurol Neurosurg 104:221–227
pubmed: 12127658
doi: 10.1016/S0303-8467(02)00042-2
Brassington JC, Marsh NV (1998) Neuropsychological aspects of multiple sclerosis. Neuropsychol Rev 8:43–77
pubmed: 9658410
doi: 10.1023/A:1025621700003
DeLuca J, Barbieri-Berger S, Johnson SK (1994) The nature of memory impairments in multiple sclerosis: acquisition versus retrieval. J Clin Exp Neuropsychol 16:183–189
pubmed: 8021305
doi: 10.1080/01688639408402629
Rao SM, Grafman J, DiGuilio D et al (1993) Memory dysfunction in multiple sclerosis: its relation to working memory, semantic encoding and implicit learning. Neuropsychology 7:364–374
doi: 10.1037/0894-4105.7.3.364
Rao SM, Leo GJ, Bernardin L et al (1991) Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology 41(5):685–691
pubmed: 2027484
doi: 10.1212/WNL.41.5.685
Filley CM (2012) White matter dementia. Ther Adv Neurol Disord 5(5):267–277
pubmed: 22973423
pmcid: 3437529
doi: 10.1177/1756285612454323
Benedict RH, Bobholz JH (2007) Multiple sclerosis. Semin Neurol 27(1):78–85
pubmed: 17226744
doi: 10.1055/s-2006-956758
Amato MP, Ponziani G, Siracusa G et al (2001) Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 years. Arch Neurol 58(10):1602–1606
pubmed: 11594918
doi: 10.1001/archneur.58.10.1602
Strober LB, Rao SM, Lee JC, Fischer E et al (2014) Cognitive impairment in multiple sclerosis: an 18year follow-up study. Mult Scler Relat Disord 3:473–481
pubmed: 25877059
doi: 10.1016/j.msard.2014.03.004
Schwid SR, Goodman AD, Weinstein A et al (2007) Cognitive function in relapsing multiple sclerosis: minimal changes in a 10-year clinical trial. J Neurol Sci 255(1):57–63
pubmed: 17331542
doi: 10.1016/j.jns.2007.01.070
Potagas C, Giogkaraki E, Koutsis G et al (2007) Cognitive impairment in different MS subtypes and clinically isolated syndromes. J Neurol Sci 267(1):100–106
pubmed: 17997417
Kurtzke JF (1998) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33(11):1444–1452
doi: 10.1212/WNL.33.11.1444
Lechner-Scott J, Kappos L, Hofman M et al (2003) Can the Expanded Disability Status Scale be assessed by telephone? Mult Scler 9(2):154–159
pubmed: 12708811
doi: 10.1191/1352458503ms884oa
Mantzavinou P (2016) Rao’s brief repeatable battery in multiple sclerosis. Normative data in the Greek population (oral presentation). In: Cognitive impairment in MS: from pathology to phenomenology, Poros, Greece, 17–20 June, 2016 (in Greek)
Achiron A, Chapman J, Magalashvili D et al (2013) Modeling of cognitive impairment by disease duration in multiple sclerosis: a cross-sectional study. PLoS ONE 8(8):e71058
pubmed: 23936485
pmcid: 3731335
doi: 10.1371/journal.pone.0071058
Jønsson A, Andresen J, Storr L et al (2006) Cognitive impairment in newly diagnosed multiple sclerosis patients: a 4-year follow-up study. J Neurol Sci 245(1–2):77–85
pubmed: 16647089
doi: 10.1016/j.jns.2005.09.016
Mariani C, Farina E, Cappa SF et al (1991) Neuropsychological assessment in multiple sclerosis: a follow-up study with magnetic resonance imaging. J Neurol 238(7):395–400
pubmed: 1960544
doi: 10.1007/BF00319859
Patti F, Failla G, Ciancio MR et al (1998) Neuropsychological, neuroradiological and clinical findings in multiple sclerosis. A 3 year follow-up study. Eur J Neurol 5(3):283–286
pubmed: 10210843
doi: 10.1046/j.1468-1331.1998.530283.x
Uher T, Blahova-Dusankova J, Horakova D et al (2014) Longitudinal MRI and neuropsychological assessment of patients with clinically isolated syndrome. J Neurol 261(9):1735–1744
pubmed: 24952618
doi: 10.1007/s00415-014-7413-9
Piras MR, Magnano I, Canu ED et al (2003) Longitudinal study of cognitive dysfunction in multiple sclerosis: neuropsychological, neuroradiological, and neurophysiological findings. J Neurol Neurosurg Psychiatry 74(7):878–885
pubmed: 12810771
pmcid: 1738564
doi: 10.1136/jnnp.74.7.878
Glanz BI, Healy BC, Hviid LE et al (2012) Cognitive deterioration in patients with early multiple sclerosis: a 5-year study. J Neurol Neurosurg Psychiatry 83(1):38–43
pubmed: 21746743
doi: 10.1136/jnnp.2010.237834
Audoin B, Ibarrola D, Ranjeva JP et al (2003) Compensatory cortical activation observed by fMRI during a cognitive task at the earliest stage of multiple sclerosis. Hum Brain Mapp 20(2):51–58
pubmed: 14505331
doi: 10.1002/hbm.10128
pmcid: 6872003
Mainero C, Caramia F, Pozzilli C et al (2004) fMRI evidence of brain reorganization during attention and memory tasks in multiple sclerosis. Neuroimage 21(3):858–867
pubmed: 15006652
doi: 10.1016/j.neuroimage.2003.10.004
Rocca MA, Valsasina P, Ceccarelli A et al (2009) Structural and functional MRI correlates of Stroop control in benign MS. Hum Brain Mapp 30(1):276–290
pubmed: 18041737
doi: 10.1002/hbm.20504
Filippi M, Rocca MA (2013) Present and future of fMRI in multiple sclerosis. Expert Rev Neurother 13(sup2):27–31
pubmed: 24289839
doi: 10.1586/14737175.2013.865871
Leavitt VM, Wylie G, Genova HM et al (2012) Altered effective connectivity during performance of an information processing speed task in multiple sclerosis. Mult Scler 18(4):409–417
pubmed: 21965419
doi: 10.1177/1352458511423651
Pardini M, Uccelli A, Grafman J et al (2014) Isolated cognitive relapses in multiple sclerosis. J Neurol Neurosurg Psychiatry 85(9):1035–1037
pubmed: 24686566
doi: 10.1136/jnnp-2013-307275
Ribbons K, Lea R, Schofield PW et al (2016) Anxiety levels are independently associated with cognitive performance in an Australian multiple sclerosis patient cohort. J Neuropsychiatry Clin Neurosci 29(2):128–134
pubmed: 27899051
doi: 10.1176/appi.neuropsych.16050085
Amato MP, Ponziani G, Pracucci G et al (1995) Cognitive impairment in early-onset multiple sclerosis: pattern, predictors, and impact on everyday life in a 4-year follow-up. Arch Neurol 52(2):168–172
pubmed: 7848126
doi: 10.1001/archneur.1995.00540260072019
Bsteh G, Ehling R, Lutterotti A et al (2016) Long term clinical prognostic factors in relapsing-remitting multiple sclerosis: insights from a 10-year observational study. PLoS ONE 11(7):e0158978
pubmed: 27391947
pmcid: 4938610
doi: 10.1371/journal.pone.0158978
Drew M, Tippett LJ, Starkey NJ et al (2008) Executive dysfunction and cognitive impairment in a large community-based sample with multiple sclerosis from New Zealand: a descriptive study. Arch Clin Neuropsychol 23(1):1–9
pubmed: 17981008
doi: 10.1016/j.acn.2007.09.005