High-sensitivity Troponin I Predicts Galectin-3 in Chronic Kidney Disease Patients.
Asian ancestry
Brain
Chronic renal failure
Galectin-3
Natriuretic peptide
Troponin I
Journal
International urology and nephrology
ISSN: 1573-2584
Titre abrégé: Int Urol Nephrol
Pays: Netherlands
ID NLM: 0262521
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
21
10
2019
accepted:
13
01
2020
pubmed:
3
2
2020
medline:
29
12
2020
entrez:
3
2
2020
Statut:
ppublish
Résumé
Plasma galectin-3 (pG3) regulates inflammation. B-type natriuretic peptide (BNP), high-sensitivity Troponin I (hsTnI), and pG3 concentrations are elevated in chronic kidney disease (CKD) patients. The associations of pG3 with hsTnI/BNP are unclear. We explored the relationship of hsTnI and BNP with pG3 in Asian CKD patients and healthy controls. We retrieved prospectively collected frozen plasma samples from 163 stable CKD patients and 105 healthy controls. BNP, hsTnI and pG3 were assayed. pG3 was assessed for associations with age, gender, ethnicity, blood pressures; height, weight, body mass index (BMI), previously diagnosed CKD, diabetes, hypertension, coronary artery disease, estimated glomerular filtration rate (eGFR); C-reactive protein, beta-trace protein, 24 h urine protein, serum albumin, uric acid and cystatin C. We created two models predicting pG3 using multiple linear regression. Akaike Information Criterion (AIC) was used for comparison. Significance was taken at P < 0.05. CKD versus healthy participants: mean BMI (28.2 vs. 24.9 kg/m BNP and hsTnI are associated with pG3 in Asian CKD patients. hsTnI is a better predictor of pG3.
Identifiants
pubmed: 32008204
doi: 10.1007/s11255-020-02390-5
pii: 10.1007/s11255-020-02390-5
doi:
Substances chimiques
Biomarkers
0
Blood Proteins
0
Galectin 3
0
Galectins
0
LGALS3 protein, human
0
Troponin T
0
Natriuretic Peptide, Brain
114471-18-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
533-540Subventions
Organisme : National University Health System Clinician Scientist Program-Residency
ID : 2014
Organisme : National Medical Research Council
ID : Blockvote
Organisme : Ministry of Education Academic Research Fund Tier 1
ID : 2008
Organisme : National Kidney Foundation Singapore
ID : NKFRC/2011/07/21
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