Hemophagocytic Lymphohistiocytosis in a Patient with Rheumatoid Arthritis on Pembrolizumab for Lung Adenocarcinoma.
hemophagocytic lymphohistiocytosis
immune checkpoint inhibitors
immune-related adverse event
lung cancer
pembrolizumab
rheumatoid arthritis
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 Apr 2020
15 Apr 2020
Historique:
pubmed:
6
2
2020
medline:
2
10
2020
entrez:
4
2
2020
Statut:
ppublish
Résumé
Immune checkpoint inhibitors have changed the landscape of classic cancer treatment. However, their use is associated with the emergence of new adverse events. An elderly man with rheumatoid arthritis was started on pembrolizumab for newly diagnosed advanced lung cancer. He subsequently developed hemophagocytic lymphohistiocytosis (HLH), which is potentially fatal but has not been properly established as an immune checkpoint inhibition-induced event. We herein report the case of a patient with pembrolizumab-induced HLH.
Identifiants
pubmed: 32009093
doi: 10.2169/internalmedicine.3889-19
pmc: PMC7205536
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
pembrolizumab
DPT0O3T46P
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1075-1080Références
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