Reduced bacterial adhesion with parylene coating: Potential implications for Micra transcatheter pacemakers.
Anti-Bacterial Agents
/ pharmacology
Bacterial Adhesion
/ drug effects
Coated Materials, Biocompatible
Colony Count, Microbial
Equipment Contamination
Pacemaker, Artificial
/ microbiology
Polymers
/ pharmacology
Pseudomonas aeruginosa
/ drug effects
Staphylococcus aureus
/ drug effects
Xylenes
/ pharmacology
Micra
cardiac implantable electronic device
infection
pacemaker
parylene
Journal
Journal of cardiovascular electrophysiology
ISSN: 1540-8167
Titre abrégé: J Cardiovasc Electrophysiol
Pays: United States
ID NLM: 9010756
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
13
12
2019
revised:
08
01
2020
accepted:
14
01
2020
pubmed:
6
2
2020
medline:
16
12
2020
entrez:
4
2
2020
Statut:
ppublish
Résumé
Infections of cardiac implantable electronic devices remain a prevalent health concern necessitating the advent of novel preventative strategies. Based on the observation that bacterial infections of the Micra transcatheter pacemaker device are extremely rare, we examine the effect of parylene coating on bacterial adhesion and growth. Bacterial growth was compared on polyurethane coated, bare, or parylene coated titanium surfaces. Eight test samples per bacterial species and material combination were incubated with Staphylococcus Aureus or Pseudomonas aeruginosa for 24 hours and then assayed for bacterial growth. The surface contact angle was also characterized by measuring the angle between the tangent to the surface of a liquid droplet made with the surface of the solid sample. The mean bacterial colony counts were significantly reduced for both parylene coated titanium versus bare samples (3.69 ± 0.27 and 4.80 ± 0.48 log[CFU/mL] respectively for S. aureus [P < .001] and 5.51 ± 0.27 and 6.08 ± 0.11 log[CFU/mL] respectively for P. aeruginosa [P < .001]), and for parylene coated titanium versus polyurethane samples (4.27 ± 0.42 and 5.40 ± 0.49 log[CFU/mL] respectively for S. aureus [P < .001] and 4.23 ± 0.42 and 4.84 ± 0.32 log[CFU/mL] respectively for P. aeruginosa [P = .006]). Parylene coated titanium samples had a higher contact angle compared with bare titanium, but lower compared with polyurethane (mean contact angle 87.5 ± 3.1 degrees parylene, 73.3 ± 3.7 degrees titanium [P < .001 vs parylene], and 94.8 ± 3.7 degrees polyurethane [P = .002 vs parylene]). Parylene coating significantly reduced the ability of bacteria to grow in colony count assays suggesting that this could contribute to the reduction of bacterial infections of Micra transcatheter pacemakers.
Substances chimiques
Anti-Bacterial Agents
0
Coated Materials, Biocompatible
0
Polymers
0
Xylenes
0
parylene
25722-33-2
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
712-717Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 Wiley Periodicals, Inc.
Références
Voigt A, Shalaby A, Saba S. Continued rise in rates of cardiovascular implantable electronic device infections in the United States: temporal trends and causative insights. Pacing Clin Electrophysiol. 2010;33(4):414-419.
Sridhar ARM, Lavu M, Yarlagadda V, et al. Cardiac implantable electronic device-related infection and extraction trends in the U.S. Pacing Clin Electrophysiol. 2017;40(3):286-293.
Dai M, Cai C, Vaibhav V, et al. Trends of cardiovascular implantable electronic device infection in 3 decades: a population-based study. JACC Clin Electrophysiol. 2019;5(9):1071-1080.
Chamis AL, Peterson GE, Cabell CH, et al. Staphylococcus Aureus bacteremia in patients with permanent pacemakers or implantable cardioverter-defibrillators. Circulation. 2001;104(9):1029-1033.
Sohail MR, Palraj BR, Khalid S, et al. Predicting risk of endovascular device infection in patients with Staphylococcus Aureus bacteremia (PREDICT-SAB). Circ Arrhythm Electrophysiol. 2015;8(1):137-144.
Maskarinec SA, Thaden JT, Cyr DD, Ruffin F, Souli M, Fowler VG. The risk of cardiac device-related infection in bacteremic patients is species specific: results of a 12-year prospective cohort. Open Forum Infect Dis. 2017;4(3):ofx132.
Reynolds D, Duray GZ, Omar R, et al. A leadless intracardiac transcatheter pacing system. N Engl J Med. 2016;374(6):533-541.
Duray GZ, Ritter P, El-Chami M, et al. Long-term performance of a transcatheter pacing system: 12-month results from the Micra transcatheter pacing study. Heart Rhythm. 2017;14(5):702-709.
Reddy VY, Exner DV, Cantillon DJ, et al. Percutaneous implantation of an entirely intracardiac leadless pacemaker. N Engl J Med. 2015;373(12):1125-1135.
El-Chami MF, Al-Samadi F, Clementy N, et al. Updated performance of the Micra transcatheter pacemaker in the real-world setting: a comparison to the investigational study and a transvenous historical control. Heart Rhythm. 2018;15(12):1800-1807.
El-Chami MF, Soejima K, Piccini JP, et al. Incidence and outcomes of systemic infections in patients with leadless pacemakers: data from the Micra IDE study. Pacing Clin Electrophysiol. 2019;42(8):1105-1110.
Medtronic. Micra Transcatheter Pacing System MC1VR01 Manual. 2016. http://manuals.medtronic.com/content/dam/emanuals/crdm/CONTRIB_231758.pdf
Kertes P, Mond H, Sloman G, Vohra J, Hunt D. Comparison of lead complications with polyurethane tined, silicone rubber tined, and wedge tip leads: clinical experience with 822 ventricular endocardial lads. Pacing Clin Electrophysiol. 1983;6(5 Pt 1):957-962.
Applerot G, Abu-Mukh R, Irzh A, et al. Decorating parylene-coated glass with ZnO nanoparticles for antibacterial applications: a comparative study of sonochemical, microwave, and microwave-plasma coating routes. ACS Appl Mater Interfaces. 2010;2(4):1052-1059.
Sohail MR, Henrikson CA, Braid-Forbes MJ, Forbes KF, Lerner DJ. Mortality and cost associated with cardiovascular implantable electronic device infections. Arch Intern Med. 2011;171(20):1821-1828.
Pokorney SD, Mi X, Lewis RK, et al. Outcomes associated with extraction versus capping and abandoning pacing and defibrillator leads. Circulation. 2017;136(15):1387-1395.
Vamos M, Honold J, Duray GZ, Hohnloser SH. MICRA leadless pacemaker on autopsy. JACC Clin Electrophysiol. 2016;2(5):636-637.
Kypta A, Blessberger H, Lichtenauer M, Steinwender C. Complete encapsulation of a leadless cardiac pacemaker. Clin Res Cardiol. 2016;105(1):94.
Zhou L, Tong Z, Wu G, et al. Parylene coating hinders Candida albicans adhesion to silicone elastomers and denture bases resin. Arch Oral Biol. 2010;55(6):401-409.
Rochford ET, Richards RG, Moriarty TF. Influence of material on the development of device-associated infections. Clin Microbiol Infect. 2012;18(12):1162-1167.
Wu S, Altenried S, Zogg A, Zuber F, Maniura-Weber K, Ren Q. Role of the surface nanoscale roughness of stainless steel on bacterial adhesion and microcolony formation. ACS Omega. 2018;3(6):6456-6464.
Whitehead KA, Rogers D, Colligon J, Wright C, Verran J. Use of the atomic force microscope to determine the effect of substratum surface topography on the ease of bacterial removal. Colloids Surf B Biointerfaces. 2006;51(1):44-53.
Yuan Y, Hays MP, Hardwidge PR, Kim J. Surface characteristics influencing bacterial adhesion to polymeric substrates. RSC Adv. 2017;23(7):14254-14261.