Volumetric assessment of unaffected parenchyma and Wilms' tumours: analysis of response to chemotherapy and surgery using a semi-automated segmentation algorithm in children with renal neoplasms.
Adolescent
Algorithms
Antineoplastic Agents
/ therapeutic use
Chemotherapy, Adjuvant
Child
Child, Preschool
Feasibility Studies
Female
Humans
Imaging, Three-Dimensional
/ methods
Infant
Infant, Newborn
Kidney Neoplasms
/ diagnosis
Male
Neoadjuvant Therapy
Nephrectomy
/ methods
Organ Size
Retrospective Studies
Tomography, X-Ray Computed
/ methods
Wilms Tumor
/ diagnosis
Wilms' tumour
chemotherapy response
partial nephrectomy
volumetric
Journal
BJU international
ISSN: 1464-410X
Titre abrégé: BJU Int
Pays: England
ID NLM: 100886721
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
pubmed:
6
2
2020
medline:
29
10
2020
entrez:
4
2
2020
Statut:
ppublish
Résumé
To present our proof of concept with semi-automatic image recognition/segmentation technology for calculation of tumour/parenchyma volume. We reviewed Wilms' tumours (WTs) between 2000 and 2018, capturing computed tomography images at baseline, after neoadjuvant chemotherapy (NaC) and postoperatively. Images were uploaded into MATLAB-3-D volumetric image processing software. The program was trained by two clinicians who supervised the demarcation of tumour and parenchyma, followed by automatic recognition and delineation of tumour margins on serial imaging, and differentiation from uninvolved renal parenchyma. Volume was automatically calculated for both. During the study period, 98 patients were identified. Of these, based on image quality and availability, 32 (38 affected moieties) were selected. Most patients (65%) were girls, diagnosed at age 50 ± 37 months of age. NaC was employed in 64% of patients. Surgical management included 27 radical and 11 partial nephrectomies. Automated volume assessment demonstrated objective response to NaC for unilateral and bilateral tumours (68 ± 20% and 53 ± 39%, respectively), as well as preservation on uninvolved parenchyma with partial nephrectomy (70 ± 46 cm Volumetric analysis is feasible and allows objective assessment of tumour and parenchyma volume in response to chemotherapy and surgery. Our data show changes after therapy that may be otherwise difficult to quantify. Use of such technology may improve surgical planning and quantification of response to treatment, as well as serving as a tool to predict renal reserve and long-term changes in renal function.
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
695-701Informations de copyright
© 2020 The Authors BJU International © 2020 BJU International Published by John Wiley & Sons Ltd.
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