Molecular Mechanisms of the Anti-Cancer Effects of Isothiocyanates from Cruciferous Vegetables in Bladder Cancer.
allyl isothiocyanate
benzyl isothiocyanate
bladder cancer
phenethyl isothiocyanate
sulforaphane
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
29 Jan 2020
29 Jan 2020
Historique:
received:
10
01
2020
revised:
24
01
2020
accepted:
28
01
2020
entrez:
5
2
2020
pubmed:
6
2
2020
medline:
21
11
2020
Statut:
epublish
Résumé
Bladder cancer (BC) is a representative of urological cancer with a high recurrence and metastasis potential. Currently, cisplatin-based chemotherapy and immune checkpoint inhibitors are used as standard therapy in patients with advanced/metastatic BC. However, these therapies often show severe adverse events, and prolongation of survival is unsatisfactory. Therefore, a treatment strategy using natural compounds is of great interest. In this review, we focused on the anti-cancer effects of isothiocyanates (ITCs) derived from cruciferous vegetables, which are widely cultivated and consumed in many regions worldwide. Specifically, we discuss the anti-cancer effects of four ITC compounds-allyl isothiocyanate, benzyl isothiocyanate, sulforaphane, and phenethyl isothiocyanate-in BC; the molecular mechanisms underlying their anti-cancer effects; current trends and future direction of ITC-based treatment strategies; and the carcinogenic potential of ITCs. We also discuss the advantages and limitations of each ITC in BC treatment, furthering the consideration of ITCs in treatment strategies and for improving the prognosis of patients with BC.
Identifiants
pubmed: 32013065
pii: molecules25030575
doi: 10.3390/molecules25030575
pmc: PMC7037050
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Carcinogens
0
Isothiocyanates
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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