Influence of Germline Genetics on Tacrolimus Pharmacokinetics and Pharmacodynamics in Allogeneic Hematopoietic Stem Cell Transplant Patients.

ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics Adult Aged Cytochrome P-450 CYP3A / genetics Databases, Genetic Female Genotype Germ-Line Mutation Graft vs Host Disease / genetics Hematopoietic Stem Cell Transplantation Humans Immunosuppressive Agents / pharmacokinetics Logistic Models Male Middle Aged Odds Ratio Polymorphism, Single Nucleotide Tacrolimus / pharmacokinetics Transplantation, Homologous Young Adult
ABCB1 CYP3A4/5 allogeneic hematopoietic stem cell transplant germline pharmacodynamics pharmacogenetics pharmacokinetics single nucleotide polymorphism (SNP) tacrolimus

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
29 Jan 2020
Historique:
received: 05 01 2020
revised: 24 01 2020
accepted: 25 01 2020
entrez: 5 2 2020
pubmed: 6 2 2020
medline: 18 11 2020
Statut: epublish

Résumé

Tacrolimus exhibits high inter-patient pharmacokinetics (PK) variability, as well as a narrow therapeutic index, and therefore requires therapeutic drug monitoring. Germline mutations in cytochrome P450 isoforms 4 and 5 genes (

Identifiants

DOI: 10.3390/ijms21030858 PMID: 32013193 PMC: PMC7037631
pubmed: 32013193
pii: ijms21030858
doi: 10.3390/ijms21030858
pmc: PMC7037631
pii:
doi:

Substances chimiques

ATP Binding Cassette Transporter, Subfamily B, Member 1 0
Immunosuppressive Agents 0
Cytochrome P-450 CYP3A EC 1.14.14.1
Tacrolimus WM0HAQ4WNM

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL139730
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007149
Pays : United States
Organisme : NHLBI NIH HHS
ID : 5T32HL007148-43
Pays : United States

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Auteurs

Jing Zhu (J)

The Center for Pharmacogenomics and Individualized Therapy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA.

Tejendra Patel (T)

The Center for Pharmacogenomics and Individualized Therapy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA.

Jordan A Miller (JA)

Department of Pharmacy, University of North Carolina Hospitals and Clinics, Chapel Hill, NC 27599, USA.

Chad D Torrice (CD)

The Center for Pharmacogenomics and Individualized Therapy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA.

Mehak Aggarwal (M)

The Center for Pharmacogenomics and Individualized Therapy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA.

Margaret R Sketch (MR)

The Center for Pharmacogenomics and Individualized Therapy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA.
ORCID: 0000-0003-3879-0346

Maurice D Alexander (MD)

Department of Pharmacy, University of North Carolina Hospitals and Clinics, Chapel Hill, NC 27599, USA.
Division of Practice Advancement and Clinical Education, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA.
ORCID: 0000-0003-3092-6050

Paul M Armistead (PM)

Division of Hematology and Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

James M Coghill (JM)

Division of Hematology and Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

Tatjana Grgic (T)

Department of Pharmacy, University of North Carolina Hospitals and Clinics, Chapel Hill, NC 27599, USA.

Katarzyna J Jamieson (KJ)

Division of Hematology and Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

Jonathan R Ptachcinski (JR)

Department of Pharmacy, University of North Carolina Hospitals and Clinics, Chapel Hill, NC 27599, USA.
Division of Practice Advancement and Clinical Education, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA.
ORCID: 0000-0002-9987-6613

Marcie L Riches (ML)

Division of Hematology and Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
ORCID: 0000-0003-0257-0990

Jonathan S Serody (JS)

Division of Hematology and Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

John L Schmitz (JL)

Department of Pathology & Laboratory Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.

J Ryan Shaw (JR)

Department of Pharmacy, University of North Carolina Hospitals and Clinics, Chapel Hill, NC 27599, USA.

Thomas C Shea (TC)

Division of Hematology and Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

Oscar Suzuki (O)

The Center for Pharmacogenomics and Individualized Therapy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA.

Benjamin G Vincent (BG)

Division of Hematology and Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

William A Wood (WA)

Division of Hematology and Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

Kamakshi V Rao (KV)

Department of Pharmacy, University of North Carolina Hospitals and Clinics, Chapel Hill, NC 27599, USA.
Division of Practice Advancement and Clinical Education, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA.

Tim Wiltshire (T)

The Center for Pharmacogenomics and Individualized Therapy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

Eric T Weimer (ET)

Department of Pathology & Laboratory Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
ORCID: 0000-0003-3677-5724

Daniel J Crona (DJ)

The Center for Pharmacogenomics and Individualized Therapy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA.
Department of Pharmacy, University of North Carolina Hospitals and Clinics, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
ORCID: 0000-0003-3742-8863

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'anions organiques ATP-dépendants › Sous-famille B de transporteurs à cassette liant l'ATP › Glycoprotéine P › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-3 de cytochromes P450 › Cytochrome P-450 CYP3A › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Sciences de l'information › Mémorisation et recherche des informations › Bases de données comme sujet › Bases de données factuelles › Bases de données génétiques › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation germinale › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Maladies du système immunitaire › Maladie du greffon contre l'hôte › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunosuppresseurs › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de régression › Modèles logistiques › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Odds ratio › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Composés chimiques organiques › Lactones › Tacrolimus › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation homologue › Influence of Germline Genetics on Tacrolimus...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Influence of Germline Genetics on Tacrolimus...