Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release.


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
18 02 2020
Historique:
pubmed: 6 2 2020
medline: 11 7 2020
entrez: 5 2 2020
Statut: ppublish

Résumé

Synaptotagmin 1 (Syt1) synchronizes neurotransmitter release to action potentials (APs) acting as the fast Ca

Identifiants

pubmed: 32015138
pii: 1920403117
doi: 10.1073/pnas.1920403117
pmc: PMC7035618
doi:

Substances chimiques

Neurotransmitter Agents 0
Synaptotagmin I 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3819-3827

Subventions

Organisme : Medical Research Council
ID : MC_UP_1502/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M013812/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T002786/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom

Informations de copyright

Copyright © 2020 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no competing interest.

Références

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Auteurs

Erica Tagliatti (E)

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom.

Oscar D Bello (OD)

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom.
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.

Philipe R F Mendonça (PRF)

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom.

Dimitrios Kotzadimitriou (D)

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom.

Elizabeth Nicholson (E)

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom.

Jeff Coleman (J)

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.

Yulia Timofeeva (Y)

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom.
Department of Computer Science, University of Warwick, CV4 7AL Coventry, United Kingdom.
Centre for Complexity Science, University of Warwick, CV4 7AL Coventry, United Kingdom.

James E Rothman (JE)

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom; james.rothman@yale.edu s.krishnakumar@ucl.ac.uk k.volynski@ucl.ac.uk.
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.

Shyam S Krishnakumar (SS)

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom; james.rothman@yale.edu s.krishnakumar@ucl.ac.uk k.volynski@ucl.ac.uk.
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.

Kirill E Volynski (KE)

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom; james.rothman@yale.edu s.krishnakumar@ucl.ac.uk k.volynski@ucl.ac.uk.
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.

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