Detection of Circulating Tumor Cells and Their Implications as a Biomarker for Diagnosis, Prognostication, and Therapeutic Monitoring in Hepatocellular Carcinoma.
Journal
Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
20
09
2019
accepted:
28
01
2020
pubmed:
6
2
2020
medline:
22
6
2021
entrez:
5
2
2020
Statut:
ppublish
Résumé
Hepatocellular carcinoma (HCC) is among the leading causes of worldwide cancer-related morbidity and mortality. Poor prognosis of HCC is attributed primarily to tumor presentation at an advanced stage when there is no effective treatment to achieve the long term survival of patients. Currently available tests such as alpha-fetoprotein have limited accuracy as a diagnostic or prognostic biomarker for HCC. Liver biopsy provides tissue that can reveal tumor biology but it is not used routinely due to its invasiveness and risk of tumor seeding, especially in early-stage patients. Liver biopsy is also limited in revealing comprehensive tumor biology due to intratumoral heterogeneity. There is a clear need for new biomarkers to improve HCC detection, prognostication, prediction of treatment response, and disease monitoring with treatment. Liquid biopsy could be an effective method of early detection and management of HCC. Circulating tumor cells (CTCs) are cancer cells in circulation derived from the original tumor or metastatic foci, and their measurement by liquid biopsy represents a great potential in facilitating the implementation of precision medicine in patients with HCC. CTCs can be detected by a simple peripheral blood draw and potentially show global features of tumor characteristics. Various CTC detection platforms using immunoaffinity and biophysical properties have been developed to identify and capture CTCs with high efficiency. Quantitative abundance of CTCs, as well as biological characteristics and genomic heterogeneity among the CTCs, can predict disease prognosis and response to therapy in patients with HCC. This review article will discuss the currently available technologies for CTC detection and isolation, their utility in the clinical management of HCC patients, their limitations, and future directions of research.
Identifiants
pubmed: 32017145
doi: 10.1002/hep.31165
pmc: PMC8183673
mid: NIHMS1558782
doi:
Substances chimiques
Biomarkers, Tumor
0
Epithelial Cell Adhesion Molecule
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
422-436Subventions
Organisme : NCI NIH HHS
ID : R01 CA172086
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA235340
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA233452
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA253651
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA246304
Pays : United States
Informations de copyright
© 2020 by the American Association for the Study of Liver Diseases.
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