A Comparison of Osteoblast and Osteoclast In Vitro Co-Culture Models and Their Translation for Preclinical Drug Testing Applications.
co-culture
drug testing
in vitro model
osteoblast
osteoclast
osteoporosis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Jan 2020
30 Jan 2020
Historique:
received:
02
12
2019
revised:
10
01
2020
accepted:
21
01
2020
entrez:
6
2
2020
pubmed:
6
2
2020
medline:
18
11
2020
Statut:
epublish
Résumé
As the population of western societies on average ages, the number of people affected by bone remodeling-associated diseases such as osteoporosis continues to increase. The development of new therapeutics is hampered by the high failure rates of drug candidates during clinical testing, which is in part due to the poor predictive character of animal models during preclinical drug testing. Co-culture models of osteoblasts and osteoclasts offer an alternative to animal testing and are considered to have the potential to improve drug development processes in the future. However, a robust, scalable, and reproducible 3D model combining osteoblasts and osteoclasts for preclinical drug testing purposes has not been developed to date. Here we review various types of osteoblast-osteoclast co-culture models and outline the remaining obstacles that must be overcome for their successful translation.
Identifiants
pubmed: 32019244
pii: ijms21030912
doi: 10.3390/ijms21030912
pmc: PMC7037207
pii:
doi:
Substances chimiques
Bone Density Conservation Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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