Vitamin B
Journal
Pediatrics
ISSN: 1098-4275
Titre abrégé: Pediatrics
Pays: United States
ID NLM: 0376422
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
accepted:
06
12
2019
pubmed:
6
2
2020
medline:
12
5
2020
entrez:
6
2
2020
Statut:
ppublish
Résumé
Vitamin B The study is a follow-up of a factorial randomized, double-blind, placebo-controlled trial in 1000 North Indian children. Children 6 to 30 months of age were randomly assigned to receive a placebo or 1.8 µg of vitamin B There were no differences between the intervention groups and the placebo group on the cognitive outcomes. Plasma cobalamin, folate, and total homocysteine concentrations in early childhood were associated with the cognitive outcomes at follow-up in the unadjusted models. These associations disappeared in models adjusted for relevant confounders. Our findings, from both an observational and a randomized design suggest that vitamin B
Sections du résumé
BACKGROUND AND OBJECTIVES
Vitamin B
METHODS
The study is a follow-up of a factorial randomized, double-blind, placebo-controlled trial in 1000 North Indian children. Children 6 to 30 months of age were randomly assigned to receive a placebo or 1.8 µg of vitamin B
RESULTS
There were no differences between the intervention groups and the placebo group on the cognitive outcomes. Plasma cobalamin, folate, and total homocysteine concentrations in early childhood were associated with the cognitive outcomes at follow-up in the unadjusted models. These associations disappeared in models adjusted for relevant confounders.
CONCLUSIONS
Our findings, from both an observational and a randomized design suggest that vitamin B
Identifiants
pubmed: 32019814
pii: peds.2019-2316
doi: 10.1542/peds.2019-2316
pii:
doi:
Substances chimiques
Homocysteine
0LVT1QZ0BA
Vitamin B Complex
12001-76-2
Folic Acid
935E97BOY8
Vitamin B 12
P6YC3EG204
Banques de données
ClinicalTrials.gov
['NCT00717730']
CTRI
['CTRI/2010/091/001090', 'CTRI/2016/11/007494']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 by the American Academy of Pediatrics.
Déclaration de conflit d'intérêts
POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.