Tumor Mutational Burden and


Journal

Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500

Informations de publication

Date de publication:
01 06 2020
Historique:
received: 30 10 2019
revised: 20 12 2019
accepted: 30 01 2020
pubmed: 6 2 2020
medline: 4 9 2021
entrez: 6 2 2020
Statut: ppublish

Résumé

Few patients with metastatic triple-negative breast cancer (mTNBC) benefit from immune checkpoint inhibitors (ICI). On the basis of immunotherapy response correlates in other cancers, we evaluated whether high tumor mutational burden (TMB) ≥10 nonsynonymous mutations/megabase and We identified patients with mTNBC, who consented to targeted DNA sequencing and were treated with ICIs on clinical trials between April 2014 and January 2019 at Dana-Farber Cancer Institute (Boston, MA). Objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were correlated with tumor genomic features. Sixty-two women received anti-PD-1/L1 inhibitors alone (23%) or combined with targeted therapy (19%) or chemotherapy (58%). High TMB (18%) was associated with significantly longer PFS (12.5 vs. 3.7 months; Among patients with mTNBC treated with anti-PD-1/L1 therapies, high TMB and

Identifiants

pubmed: 32019858
pii: 1078-0432.CCR-19-3507
doi: 10.1158/1078-0432.CCR-19-3507
pmc: PMC7269810
mid: NIHMS1557408
doi:

Substances chimiques

B7-H1 Antigen 0
Biomarkers, Tumor 0
CD274 protein, human 0
Immune Checkpoint Inhibitors 0
PDCD1 protein, human 0
Programmed Cell Death 1 Receptor 0
PTEN Phosphohydrolase EC 3.1.3.67
PTEN protein, human EC 3.1.3.67

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2565-2572

Subventions

Organisme : NCI NIH HHS
ID : P50 CA168504
Pays : United States

Informations de copyright

©2020 American Association for Cancer Research.

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Auteurs

Romualdo Barroso-Sousa (R)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Tanya E Keenan (TE)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Sonia Pernas (S)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.
Department of Medical Oncology, Institut Catala d'Oncologia-H.U.Bellvitge-IDIBELL, Barcelona, Spain.

Pedro Exman (P)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Esha Jain (E)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, Massachusetts.

Ana C Garrido-Castro (AC)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Melissa Hughes (M)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

Brittany Bychkovsky (B)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Renato Umeton (R)

Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, Massachusetts.
Massachusetts Institute of Technology, Cambridge, Massachusetts.

Janet L Files (JL)

Pathology, Brigham and Women's Hospital, Boston, Massachusetts.

Neal I Lindeman (NI)

Pathology, Brigham and Women's Hospital, Boston, Massachusetts.

Laura E MacConaill (LE)

Pathology, Brigham and Women's Hospital, Boston, Massachusetts.

F Stephen Hodi (FS)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Ian E Krop (IE)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Deborah Dillon (D)

Pathology, Brigham and Women's Hospital, Boston, Massachusetts.

Eric P Winer (EP)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Nikhil Wagle (N)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Nancy U Lin (NU)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Elizabeth A Mittendorf (EA)

Harvard Medical School, Boston, Massachusetts.
Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
Breast Oncology Program, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts.

Eliezer M Van Allen (EM)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. sara_tolaney@dfci.harvard.edu eliezerm_vanallen@dfci.harvard.edu.
Harvard Medical School, Boston, Massachusetts.
Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts.

Sara M Tolaney (SM)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. sara_tolaney@dfci.harvard.edu eliezerm_vanallen@dfci.harvard.edu.
Harvard Medical School, Boston, Massachusetts.

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