Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.

Animals Cell Proliferation Cytokines / metabolism Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental / drug therapy Epigenesis, Genetic / drug effects HEK293 Cells Histones / metabolism Humans Methionine / metabolism Methylation Mice, Inbred C57BL Mice, Knockout Multiple Sclerosis / drug therapy Th17 Cells / cytology
EAE SAM T cells Th17 cells histone methylation inflammation metabolism methionine

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
04 02 2020
Historique:
received: 11 04 2019
revised: 26 09 2019
accepted: 12 01 2020
entrez: 6 2 2020
pubmed: 6 2 2020
medline: 2 6 2021
Statut: ppublish

Résumé

Epigenetic modifications on DNA and histones regulate gene expression by modulating chromatin accessibility to transcription machinery. Here we identify methionine as a key nutrient affecting epigenetic reprogramming in CD4

Identifiants

DOI: 10.1016/j.cmet.2020.01.006 PMID: 32023446
pubmed: 32023446
pii: S1550-4131(20)30006-1
doi: 10.1016/j.cmet.2020.01.006
pii:
doi:

Substances chimiques

Cytokines 0
Histones 0
histone H3 trimethyl Lys4 0
Methionine AE28F7PNPL

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

250-266.e9

Subventions

Organisme : CIHR
ID : MOP-399061
Pays : Canada
Organisme : CIHR
ID : MOP-142259
Pays : Canada

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests S.H., V.C., and T.P.R. are employees and shareholders of Agios Pharmaceuticals. R.M.J. is an employee of Genentech. M.S. is an employee of Rheos Therapeutics. R.G.J. is a consultant to Agios Pharmaceuticals and is a shareholder and member of the scientific advisory board of Immunomet Therapeutics.

Auteurs

Dominic G Roy (DG)

Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.

Jocelyn Chen (J)

Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.

Victoria Mamane (V)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC H2X 0A9, Canada; Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada.

Eric H Ma (EH)

Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada; Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

Brejnev M Muhire (BM)

Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

Ryan D Sheldon (RD)

Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

Tatiana Shorstova (T)

The Lady Davis Institute of the Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada; Department of Oncology, McGill University, Montreal, QC, Canada.

Rutger Koning (R)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC H2X 0A9, Canada.

Radia M Johnson (RM)

Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada.

Ekaterina Esaulova (E)

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Human Immunology and Immunotherapy Programs, Washington University at St. Louis, St. Louis, MO 63110, USA.

Kelsey S Williams (KS)

Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

Sebastian Hayes (S)

Agios Pharmaceuticals, Cambridge, MA 02139, USA.

Mya Steadman (M)

Agios Pharmaceuticals, Cambridge, MA 02139, USA.

Bozena Samborska (B)

Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.

Amanda Swain (A)

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Human Immunology and Immunotherapy Programs, Washington University at St. Louis, St. Louis, MO 63110, USA.

Audrey Daigneault (A)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC H2X 0A9, Canada.

Victor Chubukov (V)

Agios Pharmaceuticals, Cambridge, MA 02139, USA.

Thomas P Roddy (TP)

Agios Pharmaceuticals, Cambridge, MA 02139, USA.

William Foulkes (W)

The Lady Davis Institute of the Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada.

J Andrew Pospisilik (JA)

Metabolic and Nutritional Programming, Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

Marie-Claude Bourgeois-Daigneault (MC)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC H2X 0A9, Canada; Institut du Cancer de Montréal, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université de Montréal, Montreal, QC H3T 1J4, Canada.

Maxim N Artyomov (MN)

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Human Immunology and Immunotherapy Programs, Washington University at St. Louis, St. Louis, MO 63110, USA.

Michael Witcher (M)

The Lady Davis Institute of the Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada; Department of Oncology, McGill University, Montreal, QC, Canada.

Connie M Krawczyk (CM)

Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada; Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA; Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada.

Catherine Larochelle (C)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC H2X 0A9, Canada; Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada.

Russell G Jones (RG)

Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada; Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA. Electronic address: russell.jones@vai.org.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Methionine Metabolism Shapes T Helper Cell...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Methionine Metabolism Shapes T Helper Cell...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Methionine Metabolism Shapes T Helper Cell...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Methionine Metabolism Shapes T Helper Cell...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Maladie neurologique auto-immune expérimentale › Encéphalomyélite auto-immune expérimentale › Methionine Metabolism Shapes T Helper Cell...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Methionine Metabolism Shapes T Helper Cell...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Methionine Metabolism Shapes T Helper Cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Methionine Metabolism Shapes T Helper Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Methionine Metabolism Shapes T Helper Cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Méthionine › Methionine Metabolism Shapes T Helper Cell...
questionsmedicales.fr › Métabolisme › Alkylation › Méthylation › Methionine Metabolism Shapes T Helper Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Methionine Metabolism Shapes T Helper Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Methionine Metabolism Shapes T Helper Cell...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Methionine Metabolism Shapes T Helper Cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Cellules Th17 › Methionine Metabolism Shapes T Helper Cell...