Mechanical Postconditioning Promotes Glucose Metabolism and AMPK Activity in Parallel with Improved Post-Ischemic Recovery in an Isolated Rat Heart Model of Donation after Circulatory Death.
cardiac ischemia reperfusion injury
contractile function
donation after circulatory death
glucose metabolism
postconditioning
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Jan 2020
31 Jan 2020
Historique:
received:
08
01
2020
revised:
27
01
2020
accepted:
30
01
2020
entrez:
7
2
2020
pubmed:
7
2
2020
medline:
18
11
2020
Statut:
epublish
Résumé
Donation after circulatory death (DCD) could improve donor heart availability; however, warm ischemia-reperfusion injury raises concerns about graft quality. Mechanical postconditioning (MPC) may limit injury, but mechanisms remain incompletely characterized. Therefore, we investigated the roles of glucose metabolism and key signaling molecules in MPC using an isolated rat heart model of DCD. Hearts underwent 20 minutes perfusion, 30 minutes global ischemia, and 60 minutes reperfusion with or without MPC (two cycles: 30 seconds reperfusion-30 seconds ischemia). Despite identical perfusion conditions, MPC either significantly decreased (low recovery = LoR; 32 ± 5%;
Identifiants
pubmed: 32024002
pii: ijms21030964
doi: 10.3390/ijms21030964
pmc: PMC7039237
pii:
doi:
Substances chimiques
AMP-Activated Protein Kinases
EC 2.7.11.31
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 310030149730/1
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Am J Pathol. 2000 Jun;156(6):2111-21
pubmed: 10854232
Circ Res. 2008 Jan 4;102(1):131-5
pubmed: 17967780
Trends Cell Biol. 2016 Mar;26(3):190-201
pubmed: 26616193
J Mol Cell Cardiol. 2009 May;46(5):607-9
pubmed: 19318238
J Am Coll Cardiol. 2019 Apr 2;73(12):1447-1459
pubmed: 30922476
Circ Res. 2017 Apr 28;120(9):1477-1486
pubmed: 28450365
N Engl J Med. 2007 Sep 13;357(11):1121-35
pubmed: 17855673
Cardiovasc Res. 2017 May 1;113(6):564-585
pubmed: 28453734
Eur Heart J. 2012 Jul;33(14):1787-847
pubmed: 22611136
Clin Sci (Lond). 2015 Mar;128(6):349-55
pubmed: 25456320
Heart Fail Rev. 2011 Jan;16(1):49-69
pubmed: 20571888
Biochim Biophys Acta. 2013 Apr;1833(4):848-56
pubmed: 22967513
Int J Biochem Cell Biol. 2006 Mar;38(3):414-9
pubmed: 16280253
Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2123-34
pubmed: 21421816
Int J Obes (Lond). 2008 Sep;32 Suppl 4:S29-35
pubmed: 18719595
J Pharmacol Toxicol Methods. 2000 Mar-Apr;43(2):141-52
pubmed: 11150742
Cell Physiol Biochem. 2008;22(5-6):635-44
pubmed: 19088445
Biochim Biophys Acta. 2014 Aug;1837(8):1350-61
pubmed: 24704335
Eur J Cardiothorac Surg. 2016 Jan;49(1):1-4
pubmed: 26487100
Heart Surg Forum. 2010 Feb;13(1):E52-6
pubmed: 20150042
J Biol Chem. 2005 Nov 11;280(45):37803-13
pubmed: 16154996
Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H579-88
pubmed: 12860564
Mol Cell. 2008 Apr 25;30(2):214-26
pubmed: 18439900
Circ Res. 2004 Aug 6;95(3):230-2
pubmed: 15242972
J Physiol Sci. 2012 Jul;62(4):333-41
pubmed: 22614393
Eur J Cardiothorac Surg. 2016 Jan;49(1):32-9
pubmed: 25694472
J Physiol. 2006 Jul 1;574(Pt 1):95-112
pubmed: 16690706
World J Cardiol. 2011 Jun 26;3(6):186-200
pubmed: 21772945
Transplantation. 2016 Dec;100(12):2621-2629
pubmed: 27861290
J Surg Res. 2010 Dec;164(2):175-81
pubmed: 20934717
Acta Anaesthesiol Scand. 2012 Jan;56(1):48-56
pubmed: 22103673
J Mol Cell Cardiol. 2012 Jan;52(1):48-61
pubmed: 21964191
Circ Res. 1995 Jul;77(1):88-97
pubmed: 7788886
Cardiovasc Res. 2009 Oct 1;84(1):42-53
pubmed: 19477967
Cardiovasc Drugs Ther. 2008 Oct;22(5):391-7
pubmed: 18563544
Cardiovasc Res. 2009 Nov 1;84(2):201-8
pubmed: 19666677
Crit Rev Biochem Mol Biol. 2010 Aug;45(4):276-95
pubmed: 20522000
Physiol Rev. 2005 Jul;85(3):1093-129
pubmed: 15987803
Shock. 2008 Jun;29(6):761-8
pubmed: 18496137
J Heart Lung Transplant. 2019 Jun;38(6):647-657
pubmed: 30655178
Front Physiol. 2016 Nov 22;7:543
pubmed: 27920725
Am J Physiol Regul Integr Comp Physiol. 2003 Apr;284(4):R936-44
pubmed: 12626360
Lancet. 2015 Jun 27;385(9987):2585-91
pubmed: 25888085
Cardiovasc Res. 2004 Apr 1;62(1):74-85
pubmed: 15023554
J Heart Lung Transplant. 2017 Dec;36(12):1311-1318
pubmed: 29173394
J Am Coll Cardiol. 2002 Feb 20;39(4):718-25
pubmed: 11849874
Curr Opin Organ Transplant. 2017 Jun;22(3):251-259
pubmed: 28426448
Cardiovasc Res. 2010 Aug 1;87(3):406-23
pubmed: 20448097
Am J Transplant. 2019 Feb;19(2):331-344
pubmed: 30019521
Am J Transplant. 2016 Mar;16(3):783-93
pubmed: 26663659
Trends Endocrinol Metab. 2017 Aug;28(8):545-560
pubmed: 28647324
Lancet. 2019 Oct 19;394(10207):1415-1424
pubmed: 31500849
J Heart Lung Transplant. 2019 Jul;38(7):767-777
pubmed: 30952549
Metabolism. 2017 Jun;71:107-117
pubmed: 28521863
J Clin Invest. 2004 Jun;113(11):1535-49
pubmed: 15173880
J Heart Lung Transplant. 2016 Oct;35(10):1255-1260
pubmed: 27498383