A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease.
Streptococcus pneumoniae
adaptive immune response
bacteremia
immunoglobulins
opsonization
phagocytosis
pneumonia
Journal
mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533
Informations de publication
Date de publication:
05 02 2020
05 02 2020
Historique:
entrez:
7
2
2020
pubmed:
7
2
2020
medline:
21
10
2020
Statut:
epublish
Résumé
Naturally acquired opsonic antipneumococcal antibodies are commonly found in nonvaccinated adults and confer protection against infection and colonization. Despite this, only limited data exist regarding the adaptive immune response after pneumococcal exposure. To investigate the dynamics of naturally acquired antipneumococcal immunity in relation to an episode of infection, opsonic antibody activity was studied with paired acute-phase and convalescent-phase sera obtained from 54 patients with pneumococcal community-acquired pneumonia (CAP) using an opsonophagocytic assay (OPA). Results were compared with clinical characteristics and anticapsular immunoglobulin (Ig) concentrations. Interestingly, a nonfunctional opsonic antibody response (characterized by a decreased convalescent-phase serum OPA titer compared to that of the acute-phase serum or undetectable titers in both sera) was observed in 19 (35%) patients. A nonfunctional convalescent-phase response was significantly more common among patients with invasive pneumococcal disease (i.e., bacteremia) than in patients without invasive disease (53%;
Identifiants
pubmed: 32024704
pii: 5/1/e00925-19
doi: 10.1128/mSphere.00925-19
pmc: PMC7002313
pii:
doi:
Substances chimiques
Antibodies, Bacterial
0
Pneumococcal Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Retracted Publication
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : ErratumIn
Type : RetractedandRepublishedIn
Type : RetractionIn
Informations de copyright
Copyright © 2020 Uddén et al.
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