Live-animal imaging of native haematopoietic stem and progenitor cells.

Animals Bone Remodeling Cell Movement Cell Proliferation Cell Survival Female Genes, Reporter Hematopoietic Stem Cells / metabolism Hypoxia / metabolism MDS1 and EVI1 Complex Locus Protein / genetics Male Mice Molecular Imaging Oxygen / metabolism Skull / cytology fms-Like Tyrosine Kinase 3 / genetics

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
02 2020
Historique:
received: 07 06 2018
accepted: 06 12 2019
pubmed: 7 2 2020
medline: 21 4 2020
entrez: 7 2 2020
Statut: ppublish

Résumé

The biology of haematopoietic stem cells (HSCs) has predominantly been studied under transplantation conditions

Identifiants

DOI: 10.1038/s41586-020-1971-z PMID: 32025033 PMC: PMC7021587
pubmed: 32025033
doi: 10.1038/s41586-020-1971-z
pii: 10.1038/s41586-020-1971-z
pmc: PMC7021587
mid: NIHMS1546022
doi:

Substances chimiques

MDS1 and EVI1 Complex Locus Protein 0
Mecom protein, mouse 0
Flt3 protein, mouse EC 2.7.10.1
fms-Like Tyrosine Kinase 3 EC 2.7.10.1
Oxygen S88TT14065

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

278-283

Subventions

Organisme : NCI NIH HHS
ID : R01 CA194596
Pays : United States
Organisme : NINDS NIH HHS
ID : R24 NS092986
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK123216
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128850
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL131477
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK110805
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB017274
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115577
Pays : United States
Organisme : NIDDK NIH HHS
ID : R24 DK103074
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB018464
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA175761
Pays : United States

Commentaires et corrections

Type : CommentIn

Références

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Auteurs

Constantina Christodoulou (C)

Stem Cell Program, Boston Children's Hospital, Boston, MA, USA.
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Novartis Institutes for BioMedical Research, Cambridge, MA, USA.

Joel A Spencer (JA)

Advanced Microscopy Program, Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Department of Bioengineering, University of California Merced, Merced, CA, USA.

Shu-Chi A Yeh (SA)

Advanced Microscopy Program, Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.

Raphaël Turcotte (R)

Advanced Microscopy Program, Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.

Konstantinos D Kokkaliaris (KD)

Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

Riccardo Panero (R)

Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.

Azucena Ramos (A)

Stem Cell Program, Boston Children's Hospital, Boston, MA, USA.
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.

Guoji Guo (G)

Dana Farber/Boston Children's Cancer and Blood Disorders Center, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.

Negar Seyedhassantehrani (N)

Department of Bioengineering, University of California Merced, Merced, CA, USA.

Tatiana V Esipova (TV)

Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.

Sergei A Vinogradov (SA)

Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.

Sarah Rudzinskas (S)

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.

Yi Zhang (Y)

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.

Archibald S Perkins (AS)

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.

Stuart H Orkin (SH)

Dana Farber/Boston Children's Cancer and Blood Disorders Center, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.

Raffaele A Calogero (RA)

Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.

Timm Schroeder (T)

Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

Charles P Lin (CP)

Advanced Microscopy Program, Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA. charles_lin@hms.harvard.edu.
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA. charles_lin@hms.harvard.edu.

Fernando D Camargo (FD)

Stem Cell Program, Boston Children's Hospital, Boston, MA, USA. fernando.camargo@childrens.harvard.edu.
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. fernando.camargo@childrens.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Live-animal imaging of native haematopoietic...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Remodelage osseux › Live-animal imaging of native haematopoietic...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Live-animal imaging of native haematopoietic...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Live-animal imaging of native haematopoietic...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Live-animal imaging of native haematopoietic...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes rapporteurs › Live-animal imaging of native haematopoietic...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Cellules souches hématopoïétiques › Live-animal imaging of native haematopoietic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Live-animal imaging of native haematopoietic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéine du locus du complexe MDS1 et EVI1 › Live-animal imaging of native haematopoietic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Live-animal imaging of native haematopoietic...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Imagerie moléculaire › Live-animal imaging of native haematopoietic...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › Live-animal imaging of native haematopoietic...
questionsmedicales.fr › Appareil locomoteur › Squelette › Crâne › Live-animal imaging of native haematopoietic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Tyrosine kinase-3 de type fms › Live-animal imaging of native haematopoietic...