Can Triggering Receptors Expressed on Myeloid Cells be used for Diagnosis of
CRP
ELISA
Enteric fever
PCT
blood culture
sTREM1
Journal
Endocrine, metabolic & immune disorders drug targets
ISSN: 2212-3873
Titre abrégé: Endocr Metab Immune Disord Drug Targets
Pays: United Arab Emirates
ID NLM: 101269157
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
09
2019
revised:
03
12
2019
accepted:
03
12
2019
pubmed:
7
2
2020
medline:
2
9
2021
entrez:
7
2
2020
Statut:
ppublish
Résumé
There is a need for rapid and accurate diagnostic biomarker for diagnosis of Salmonella fever. The aim of the present study was to assess the importance of procalcitonin (PCT), Soluble Triggering Receptors expressed on Myeloid Cells 1 (sTREM1) and C- reactive protein (CRP) in the diagnosis of enteric fever with positive blood culture for S.typhi. Blood samples were withdrawn from 200 patients with suspected enteric fever and subjected for the determination of CRP, PCT and sTREM-1. The sensitivity and specificity for PCT cut off were 97.7% & 82.5%, for CRP the sensitivity and specificity were 95.3% and 77% and for s-TREM-1 the sensitivity and specificity were 95.3% & 77%. S-TREM-1 may be considered as a novel biomarker for the diagnosis of enteric fever with good sensitivity and specificity.
Sections du résumé
BACKGROUND
BACKGROUND
There is a need for rapid and accurate diagnostic biomarker for diagnosis of Salmonella fever.
AIMS
OBJECTIVE
The aim of the present study was to assess the importance of procalcitonin (PCT), Soluble Triggering Receptors expressed on Myeloid Cells 1 (sTREM1) and C- reactive protein (CRP) in the diagnosis of enteric fever with positive blood culture for S.typhi.
METHODS
METHODS
Blood samples were withdrawn from 200 patients with suspected enteric fever and subjected for the determination of CRP, PCT and sTREM-1.
RESULTS
RESULTS
The sensitivity and specificity for PCT cut off were 97.7% & 82.5%, for CRP the sensitivity and specificity were 95.3% and 77% and for s-TREM-1 the sensitivity and specificity were 95.3% & 77%.
CONCLUSION
CONCLUSIONS
S-TREM-1 may be considered as a novel biomarker for the diagnosis of enteric fever with good sensitivity and specificity.
Identifiants
pubmed: 32026790
pii: EMIDDT-EPUB-104256
doi: 10.2174/1871530320666200206120151
doi:
Substances chimiques
Biomarkers
0
Procalcitonin
0
TREM1 protein, human
0
Triggering Receptor Expressed on Myeloid Cells-1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1488-1493Informations de copyright
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